{"id":"W2172486832","doi":"10.1107/s2053230x15016064","title":"Structural analysis of SepL, an enteropathogenic<i>Escherichia coli</i>type III secretion-system gatekeeper protein","year":2015,"lang":"en","type":"article","venue":"Acta Crystallographica Section F Structural Biology Communications","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Lawrence Berkeley National Laboratory; Ciência sem Fronteiras; Canadian Institutes of Health Research; Centre for Blood Research, University of British Columbia; Ministério da Educação; Howard Hughes Medical Institute","keywords":"Secretion; Translocon; Effector; Type three secretion system; Virulence; Escherichia coli; Cytoplasm; Secretory protein; Enteropathogenic Escherichia coli; Biology; Cell biology; Transport protein; Microbiology; Type VI secretion system; Membrane protein; Inner membrane; Membrane; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001441973,0.0002459053,0.0002155869,0.0001666135,0.0002733644,0.0003036362,0.0004026522,0.0002403423,0.0006759794],"category_scores_gemma":[0.0002976705,0.0001065809,0.0001774202,0.0002607233,0.0002191861,0.0001554714,0.0001697668,0.0004283587,0.0002150702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009169473,"about_ca_system_score_gemma":0.0005327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00470688,"about_ca_topic_score_gemma":0.004233672,"domain_scores_codex":[0.9999477,0.000007395618,0.000002546386,0.00001015717,0.0000230075,0.000009257289],"domain_scores_gemma":[0.9999025,0.00001804637,0.00002418034,0.000004696848,0.00002022598,0.00003026589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001321562,0.00037622,0.009478532,0.0004698518,0.00005095135,0.003149979,0.0002900573,0.008212429,0.9596516,0.001976621,0.002727423,0.0122948],"study_design_scores_gemma":[0.0003461455,0.001019377,0.1208863,0.0001193386,0.000163212,0.004224471,0.001100951,0.1091387,0.7219893,0.00106305,0.03983469,0.0001144076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996327,0.0007503544,0.0007235699,0.0001841541,0.00001772874,0.00001362849,0.0008570811,0.00003718257,0.001089385],"genre_scores_gemma":[0.9917584,0.0007831777,0.0022754,0.00009585573,0.000008486109,0.00001326731,0.003853442,0.00002040174,0.001191464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00470688,"threshold_uncertainty_score":0.009359002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02917134125312597,"score_gpt":0.3023807547953589,"score_spread":0.2732094135422329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}