{"id":"W2172574503","doi":"10.2337/db14-0810","title":"The ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated With Progressive Insulin Resistance and Decreased Functional β-Cell Mass in Mice","year":2015,"lang":"en","type":"article","venue":"Diabetes","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Erasmus+; National Institute of Diabetes and Digestive and Kidney Diseases; Cystic Fibrosis Canada","keywords":"Cystic fibrosis transmembrane conductance regulator; Internal medicine; Endocrinology; ΔF508; Insulin resistance; Cystic fibrosis; Glucose homeostasis; Biology; Mutant; Insulin; Impaired glucose tolerance; Medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000772865,0.0001566318,0.0002454501,0.00008347218,0.00009849303,0.00006711786,0.0001206057,0.00006535211,0.00001039262],"category_scores_gemma":[0.001466207,0.00008996317,0.00002622065,0.0006038189,0.0003275854,0.0001605635,0.00001010514,0.0002493401,0.000003637914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001368389,"about_ca_system_score_gemma":0.0002318511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001787052,"about_ca_topic_score_gemma":0.0001858849,"domain_scores_codex":[0.9982049,0.0002568425,0.0002618282,0.0002910454,0.0006197528,0.0003656204],"domain_scores_gemma":[0.997883,0.001462772,0.0001163793,0.0001978809,0.0002224195,0.0001175441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01781538,0.002146359,0.4093672,0.001949972,0.0004958948,0.0005744974,0.01529523,0.0004599826,0.5334594,0.000727533,0.009754498,0.007954],"study_design_scores_gemma":[0.02056281,0.001573592,0.8776993,0.002468474,0.0001673329,0.00001654164,0.005469725,0.006729448,0.07826212,0.004592401,0.00188337,0.0005748976],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884638,0.008052094,0.00002837569,0.002363364,0.00003203634,0.000785769,0.00004552516,0.00002136532,0.0002077],"genre_scores_gemma":[0.9978938,0.00003661787,0.001242162,0.000227083,0.00002963706,0.0002337972,0.00007523427,0.00001876517,0.0002429124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4683321,"threshold_uncertainty_score":0.3668591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01464861437473782,"score_gpt":0.252133350548674,"score_spread":0.2374847361739362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}