{"id":"W2172594636","doi":"10.1016/j.bpj.2015.09.021","title":"Vesicle Leakage Reflects the Target Selectivity of Antimicrobial Lipopeptides from Bacillus subtilis","year":2015,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Tobacco Research Unit; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Bayer CropScience; Deutsche Forschungsgemeinschaft","keywords":"Lipopeptide; Bacillus subtilis; Phosphatidylethanolamine; Vesicle; Liposome; Membrane; Antimicrobial; Chemistry; Phosphatidylcholine; Ergosterol; Biophysics; Antimicrobial peptides; Lipid bilayer; Sterol; Biochemistry; Bacteria; Peptide; Biology; Cholesterol; Phospholipid; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003014608,0.0002211297,0.0004234553,0.00005351154,0.0003065383,0.00006412734,0.0003969441,0.0001677059,0.0001673495],"category_scores_gemma":[0.000156805,0.0001455151,0.0002418388,0.0001840757,0.0005762696,0.000266446,0.0001403215,0.0006519805,0.000215819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000585489,"about_ca_system_score_gemma":0.000165215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004736844,"about_ca_topic_score_gemma":0.00001742314,"domain_scores_codex":[0.9985902,0.0003302461,0.000343287,0.0002360568,0.00008741397,0.000412815],"domain_scores_gemma":[0.9989977,0.0002299079,0.0002785833,0.0002469166,0.0001804923,0.00006634606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003342342,0.000254543,0.0005772922,0.000004611384,0.0001714156,0.00001057402,0.000609609,0.00002470744,0.9654117,0.0001306515,0.03122398,0.001246643],"study_design_scores_gemma":[0.001049178,0.0002675948,0.003217424,0.00003959942,0.00005793893,0.0001327726,0.000361967,0.00001155891,0.9856939,0.0004537605,0.008508573,0.0002057128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969922,0.0002230469,0.0003641424,0.0006747618,0.0008211057,0.0001038816,0.0001058398,0.00003541611,0.000679546],"genre_scores_gemma":[0.9982482,0.00003649777,0.0003760487,0.0002537864,0.0004893781,0.000001577933,0.00002473654,0.00002202266,0.0005477453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0227154,"threshold_uncertainty_score":0.5933933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02348868839578169,"score_gpt":0.2434152788066072,"score_spread":0.2199265904108255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}