{"id":"W2172727255","doi":"10.1158/1535-7163.mct-15-0679","title":"GC1118, an Anti-EGFR Antibody with a Distinct Binding Epitope and Superior Inhibitory Activity against High-Affinity EGFR Ligands","year":2016,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"Ministry of Health and Welfare; Neurosciences Research Foundation","keywords":"Cetuximab; Panitumumab; Epitope; Monoclonal antibody; Antibody; Cancer research; Epidermal growth factor receptor; EGFR inhibitors; Colorectal cancer; Chemistry; Cancer; In vivo; Pharmacology; Receptor; Biology; Medicine; Biochemistry; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001539446,0.0003758606,0.0002653135,0.0002508257,0.0001140892,0.0003057244,0.0003256161,0.000496301,0.0009401574],"category_scores_gemma":[0.0001390983,0.0001041501,0.0001613934,0.000227263,0.0002869493,0.0002367059,0.0002094938,0.0007593897,0.0003951263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000536678,"about_ca_system_score_gemma":0.0003587482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007549206,"about_ca_topic_score_gemma":0.001238697,"domain_scores_codex":[0.9998657,0.00002415879,0.000008086534,0.00003064922,0.00003981463,0.00003166607],"domain_scores_gemma":[0.9999341,0.00001379107,0.00001382027,0.000009087893,0.000009152857,0.00002008771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001729202,0.000128164,0.000421469,0.0001039898,0.00001179064,0.0001468727,0.00002004354,0.0002657994,0.9853837,0.0005122318,0.0003557946,0.01247719],"study_design_scores_gemma":[0.0001188747,0.001469537,0.002448002,0.00000984596,0.00002912211,0.001850734,0.00001306302,0.00115793,0.9808012,0.00006977841,0.01202111,0.00001082944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805802,0.00821382,0.004961113,0.0002918044,0.00005236897,0.0001211597,0.0002130477,0.0001221172,0.005444216],"genre_scores_gemma":[0.9836497,0.003241261,0.006926257,0.0002220203,0.00002067512,0.00006325447,0.0008069915,0.0000271126,0.005042773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009401574,"threshold_uncertainty_score":0.003893912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02825514190910116,"score_gpt":0.3251876591008646,"score_spread":0.2969325171917634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}