{"id":"W2172767004","doi":"10.1158/2159-8290.cd-15-0987","title":"T Regulatory Cells Gone Bad: An Oncogenic Immune Response against Enterotoxigenic <i>B. fragilis</i> Infection Leads to Colon Cancer","year":2015,"lang":"en","type":"letter","venue":"Cancer Discovery","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Immune system; Colorectal cancer; Biology; Cancer; Enterotoxigenic Escherichia coli; Immunology; Gene; Genetics; Enterotoxin; Escherichia coli","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0005226564,0.0006688504,0.000674326,0.0001955557,0.0001775997,0.0001324108,0.0005070769,0.001427599,0.00006840598],"category_scores_gemma":[0.00002849074,0.0006935016,0.0003465943,0.0002266045,0.0001527859,0.00003619851,0.0002792159,0.001031053,0.00006163371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001015337,"about_ca_system_score_gemma":0.00254138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001150161,"about_ca_topic_score_gemma":0.001208085,"domain_scores_codex":[0.996427,0.0004875479,0.0006102953,0.001245046,0.0003479432,0.0008821585],"domain_scores_gemma":[0.9977463,0.0000196918,0.0003759214,0.001333165,0.0002506976,0.0002742192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001014642,0.00004066403,0.0002699731,0.0001107596,0.00008928078,0.00001653685,0.00006698209,0.0001515554,0.5338925,1.532665e-7,0.4640351,0.0003118193],"study_design_scores_gemma":[0.0006949808,0.0006603731,0.001924626,0.0002038535,0.00009393488,0.000007758832,0.000009205158,0.000001665824,0.2356497,0.000002331626,0.7601028,0.0006486925],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.9618975,0.008817033,0.00005084939,0.02296294,0.003488441,0.001157512,0.001486392,0.00004597746,0.00009335364],"genre_scores_gemma":[0.2991215,0.01007199,0.00005979973,0.6403283,0.01262878,0.001385508,0.004430155,0.0004237039,0.03155023],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.662776,"threshold_uncertainty_score":0.9998688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01462267793477046,"score_gpt":0.2884545714435541,"score_spread":0.2738318935087836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}