{"id":"W2172823456","doi":"10.1016/j.bmcl.2005.09.021","title":"Pulvinones as bacterial cell wall biosynthesis inhibitors","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Enterococcus faecalis; Streptococcus pneumoniae; Bacteria; Chemistry; Enzyme; Microbiology; Biosynthesis; Bacterial cell structure; Penicillin; Antibacterial agent; Antibiotics; Enterococcus; Streptococcaceae; Biochemistry; Biology; Escherichia coli; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002107532,0.0004851912,0.0002650925,0.0003178025,0.0002022682,0.0005455233,0.0003950529,0.0003574326,0.002875637],"category_scores_gemma":[0.0001800675,0.0002031804,0.0001991679,0.0001755436,0.0002101929,0.0004870667,0.000418721,0.0007202688,0.0007136515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004002532,"about_ca_system_score_gemma":0.0001939323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005851762,"about_ca_topic_score_gemma":0.001091202,"domain_scores_codex":[0.9999141,0.00001917463,0.000006397559,0.00001085806,0.00001630637,0.00003313847],"domain_scores_gemma":[0.9999392,0.00001608744,0.000009540824,0.000009484324,0.000006919149,0.0000188002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001555761,0.0001973648,0.0004005022,0.000425488,0.00004414485,0.0008747452,0.0001436532,0.002817889,0.9124296,0.006135148,0.002248838,0.07272681],"study_design_scores_gemma":[0.0002261968,0.001207206,0.000921089,0.00004595146,0.00004400785,0.0003796835,0.00003224784,0.001465877,0.9542328,0.0004948046,0.04092809,0.00002218588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8517724,0.07881752,0.01675641,0.001383876,0.001343835,0.0002695648,0.001394045,0.0009671603,0.04729522],"genre_scores_gemma":[0.9599438,0.0211344,0.002979934,0.0003547775,0.00007044791,0.00006597288,0.0006431491,0.00005568442,0.01475188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002875637,"threshold_uncertainty_score":0.009619951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006718256731812102,"score_gpt":0.2067930227136978,"score_spread":0.2000747659818857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}