{"id":"W2172823456","doi":"10.1016/j.bmcl.2005.09.021","title":"Pulvinones as bacterial cell wall biosynthesis inhibitors","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Enterococcus faecalis; Streptococcus pneumoniae; Bacteria; Chemistry; Enzyme; Microbiology; Biosynthesis; Bacterial cell structure; Penicillin; Antibacterial agent; Antibiotics; Enterococcus; Streptococcaceae; Biochemistry; Biology; Escherichia coli; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002688647,0.0004421997,0.0005398993,0.00007789233,0.0001284354,0.00004147431,0.00029163,0.0002833036,0.006968001],"category_scores_gemma":[0.0002944551,0.0003429192,0.000210587,0.0002955162,0.0002424037,0.0001150638,0.0000850806,0.0004523452,0.0005577966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002586209,"about_ca_system_score_gemma":0.0001591618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007783539,"about_ca_topic_score_gemma":0.000002674235,"domain_scores_codex":[0.9976017,0.00003300825,0.000537767,0.0007013581,0.0005197196,0.0006064437],"domain_scores_gemma":[0.9986958,0.00007280972,0.0001900003,0.0005446417,0.00008943737,0.0004073196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002602983,0.0001688625,0.000188255,0.0002408379,0.00006484313,0.00009567607,0.0001015213,8.459085e-8,0.9544552,7.944399e-7,0.04064522,0.003778425],"study_design_scores_gemma":[0.0009766819,0.00005455728,0.0004611658,0.0001789081,0.0002337153,0.0003519852,0.00007837251,0.00000312966,0.8786243,0.000001242998,0.118696,0.000339975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9122199,0.0006062271,0.000002432027,0.08486665,0.0003622187,0.0002495304,0.00001322182,0.0001583393,0.001521426],"genre_scores_gemma":[0.9844945,0.0001390325,0.0003873087,0.007364712,0.005794719,0.00000196084,0.00006692467,0.0000637206,0.00168713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07805074,"threshold_uncertainty_score":0.9999023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006718256731812102,"score_gpt":0.2067930227136978,"score_spread":0.2000747659818857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}