{"id":"W2172909145","doi":"10.1200/jco.2015.62.3918","title":"Pan Canadian Rash Trial: A Randomized Phase III Trial Evaluating the Impact of a Prophylactic Skin Treatment Regimen on Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor–Induced Skin Toxicities in Patients With Metastatic Lung Cancer","year":2015,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Rash; Randomized controlled trial; Regimen; Tyrosine-kinase inhibitor; Internal medicine; Epidermal growth factor receptor; Pharmacology; Oncology; Dermatology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003586109,0.0003085792,0.0029022,0.0003450351,0.00007155827,0.00002139126,0.0001236072,0.0001794761,0.0001172818],"category_scores_gemma":[0.00608755,0.0001417998,0.0007335484,0.0002864615,0.0002063547,0.0001684059,0.00001455728,0.000532826,0.000001469852],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003340534,"about_ca_system_score_gemma":0.01695692,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.04639325,"about_ca_topic_score_gemma":0.008089385,"domain_scores_codex":[0.9935182,0.0024175,0.002770991,0.0002586277,0.0006558696,0.0003788383],"domain_scores_gemma":[0.9921718,0.003261534,0.002844218,0.0002362199,0.0008411756,0.0006450317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9480981,0.007206899,0.003996161,0.00001789323,0.00265691,0.00008224183,0.002162058,0.00007926491,0.00002064525,0.000007625919,0.0004218829,0.03525035],"study_design_scores_gemma":[0.8364677,0.152846,0.007279489,0.0001969004,0.002412419,0.000007844013,0.0002847624,0.0001957449,0.0001172812,0.00003130739,0.00004463931,0.0001158606],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910117,0.0002927247,0.000006017386,0.002074994,0.001058393,0.005319082,0.00005721268,0.000005187951,0.0001747081],"genre_scores_gemma":[0.9980574,0.00005653819,0.0003354959,0.0002829317,0.0008422773,0.0002719674,0.00002363981,0.00003166265,0.00009805976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1456391,"threshold_uncertainty_score":0.988616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1414465993466889,"score_gpt":0.5190120435884947,"score_spread":0.3775654442418059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}