{"id":"W2172933245","doi":"10.1016/j.bmcl.2004.10.065","title":"(S,E)-N-[1-(3-Heteroarylphenyl)ethyl]-3-(2-fluorophenyl)acrylamides: synthesis and KCNQ2 potassium channel opener activity","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Coordination Chemistry and Organometallics","field":"Chemistry","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Bristol-Myers Squibb (Canada)","funders":"","keywords":"Chemistry; Acrylamide; Moiety; Potency; Stereochemistry; Potassium channel opener; Chemical synthesis; Potassium channel; Potassium; Organic chemistry; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003692769,0.000408875,0.0003023637,0.000275397,0.0002806005,0.0002146265,0.0004310955,0.0003575016,0.002304312],"category_scores_gemma":[0.000285457,0.0001865206,0.0002134558,0.0001750709,0.0002428572,0.0003928873,0.0002675665,0.0003462429,0.0007786812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003901021,"about_ca_system_score_gemma":0.0003040382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009000898,"about_ca_topic_score_gemma":0.001416276,"domain_scores_codex":[0.9997868,0.00004032082,0.00001919394,0.00004911058,0.00003103865,0.00007363252],"domain_scores_gemma":[0.9998677,0.00002466307,0.00003779826,0.00001584288,0.00001663788,0.00003733204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006976774,0.0001142754,0.0001239935,0.0001338111,0.00001216607,0.0003103373,0.00006187602,0.0005636789,0.9861113,0.001011116,0.0004472737,0.01041258],"study_design_scores_gemma":[0.0001489486,0.001216908,0.001086432,0.000008791398,0.00001930336,0.0004503441,0.0000202636,0.0005501346,0.9908848,0.0001003251,0.005494135,0.00001968302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9573463,0.005633881,0.01750648,0.000340605,0.0001741555,0.0001887667,0.0005298135,0.0004936234,0.01778641],"genre_scores_gemma":[0.985698,0.002120075,0.006261973,0.0001166571,0.00005023057,0.0001130435,0.0002673577,0.00005030085,0.005322435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002304312,"threshold_uncertainty_score":0.007708728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01171516909532727,"score_gpt":0.2142690615329091,"score_spread":0.2025538924375819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}