{"id":"W2172933245","doi":"10.1016/j.bmcl.2004.10.065","title":"(S,E)-N-[1-(3-Heteroarylphenyl)ethyl]-3-(2-fluorophenyl)acrylamides: synthesis and KCNQ2 potassium channel opener activity","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Coordination Chemistry and Organometallics","field":"Chemistry","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Bristol-Myers Squibb (Canada)","funders":"","keywords":"Chemistry; Acrylamide; Moiety; Potency; Stereochemistry; Potassium channel opener; Chemical synthesis; Potassium channel; Potassium; Organic chemistry; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003185415,0.0007560238,0.0007010956,0.00005943749,0.0003634777,0.0001346193,0.0007288838,0.0004433027,0.003266586],"category_scores_gemma":[0.0006037055,0.0007522133,0.0002122795,0.0003690209,0.0006071473,0.0003146452,0.0003259796,0.0007727315,0.00005006848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005277085,"about_ca_system_score_gemma":0.000231907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000108515,"about_ca_topic_score_gemma":0.000005426286,"domain_scores_codex":[0.9966192,0.00002744469,0.0005876092,0.001155672,0.0007549158,0.0008551267],"domain_scores_gemma":[0.9977932,0.0002782869,0.0003430469,0.0008950711,0.00009999698,0.0005904283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000899329,0.000186988,0.000202854,0.000770353,0.0001575118,0.0001407226,0.0002415155,0.00001162355,0.995708,0.000009622474,0.0005218465,0.001959006],"study_design_scores_gemma":[0.001546577,0.00001351809,0.0005864064,0.0003057497,0.0002145611,0.0003272856,0.0003889158,0.00002377239,0.9936885,0.0001123128,0.00196839,0.0008240042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836037,0.000527432,0.0005117689,0.01123041,0.0001785985,0.0001170266,0.00007824669,0.0003090927,0.00344372],"genre_scores_gemma":[0.9964781,0.0001866778,0.000241309,0.000915167,0.001142083,0.0000645265,0.00006355662,0.0001151334,0.0007934892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01287435,"threshold_uncertainty_score":0.9994929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01171516909532727,"score_gpt":0.2142690615329091,"score_spread":0.2025538924375819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}