{"id":"W2172956397","doi":"10.1021/jo0617666","title":"Synthesis of Methylene- and Difluoromethylenephosphonate Analogues of Uridine-4-phosphate and 3-Deazauridine-4-phosphate","year":2006,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo; Dalhousie University","funders":"","keywords":"Chemistry; Electrophile; Methylene; Cytidine; Uridine; Nucleoside triphosphate; Phosphate; Uridine triphosphate; Nucleoside; Stereochemistry; Nucleotide; Derivative (finance); Medicinal chemistry; Enzyme; Organic chemistry; Biochemistry; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007447646,0.000201777,0.0004003185,0.00003330283,0.00005087229,0.00001197567,0.0003592904,0.0001722937,0.00005847195],"category_scores_gemma":[0.0003512173,0.0001412125,0.0001300273,0.0001719521,0.0004195469,0.000007395867,0.0002609273,0.000202048,3.797947e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001205544,"about_ca_system_score_gemma":0.0001017636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005096562,"about_ca_topic_score_gemma":0.000003843784,"domain_scores_codex":[0.9986395,0.00006958126,0.0005621583,0.0001903786,0.0003049476,0.0002334176],"domain_scores_gemma":[0.998691,0.0001260545,0.0004857682,0.0003110407,0.0002744451,0.0001117375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002828584,0.00007737572,0.0009355535,0.0001798257,0.0001693744,0.000006594508,0.00002201369,0.000007078011,0.9968786,0.000007811569,0.0002730165,0.001159873],"study_design_scores_gemma":[0.0005462453,0.0001418775,0.001708918,0.0000699289,0.000153624,0.0002033814,0.00008270375,0.000007486415,0.9959968,0.0002334813,0.0007142675,0.0001413387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9705845,0.02861616,0.0002268674,0.0002879073,0.00002448843,0.00006730795,0.00002251949,0.000002891303,0.0001674231],"genre_scores_gemma":[0.9925235,0.00668541,0.0004388875,0.00002520084,0.0000980414,0.00000155964,0.00000779043,0.00002700746,0.0001926187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02193905,"threshold_uncertainty_score":0.575848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005205930977578753,"score_gpt":0.2197562053625509,"score_spread":0.2145502743849722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}