{"id":"W2173070859","doi":"10.1186/2051-1426-3-s2-p259","title":"Immune biomarker correlates from a Phase II study of ipilimumab (IPI) with carboplatin and paclitaxel (CP) in patients with unresectable stage III or IV metastatic melanoma (MM)","year":2015,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Ipilimumab; Carboplatin; Medicine; Paclitaxel; Metastatic melanoma; Internal medicine; Oncology; Stage (stratigraphy); Melanoma; Biomarker; Nivolumab; Chemotherapy; Immunotherapy; Cancer; Cisplatin; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001100497,0.0004468558,0.0007050433,0.0002343259,0.0002551682,0.0005429322,0.0002345709,0.0003877209,0.002298829],"category_scores_gemma":[0.001083862,0.0001674053,0.0005400137,0.0002562963,0.0001976939,0.0003203065,0.0001913554,0.001255186,0.0003736987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003573149,"about_ca_system_score_gemma":0.0003047062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000403902,"about_ca_topic_score_gemma":0.0006458151,"domain_scores_codex":[0.999761,0.00007860387,0.00002076114,0.00004677181,0.00004852496,0.00004432428],"domain_scores_gemma":[0.9993697,0.0001727466,0.0001145441,0.00004395492,0.00007628338,0.0002228603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2008689,0.01242555,0.2803003,0.0009548893,0.002270253,0.0005321744,0.000236783,0.001568243,0.1400204,0.0002214237,0.01258593,0.3480152],"study_design_scores_gemma":[0.02038784,0.162733,0.7660081,0.0000452738,0.002949126,0.001193776,0.00009078612,0.001255107,0.03080973,0.0001978631,0.01429421,0.0000351571],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924008,0.003205288,0.0004397747,0.0004213336,0.0001092727,0.000336779,0.0009861898,0.00003549447,0.00206512],"genre_scores_gemma":[0.9951457,0.0004886795,0.0004372669,0.0006346725,0.000126017,0.0001968221,0.001879698,0.00001010583,0.001080949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002298829,"threshold_uncertainty_score":0.00769037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03410340619736896,"score_gpt":0.3319590933816475,"score_spread":0.2978556871842786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}