{"id":"W2173198068","doi":"","title":"Inhibition of STAT3 using shRNA inhibits Thymidine Kinase (TK) mediated glioma cell death in vitro and abrogates Flt3L and TK dependent tumor regression in vivo.","year":2008,"lang":"en","type":"article","venue":"Cancer Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Small hairpin RNA; Cancer research; Immune system; Biology; Immunotherapy; Glioma; STAT3; In vivo; Immunology; Signal transduction; Cell culture; Cell biology; Gene knockdown","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012911,0.0003416773,0.0001808564,0.000183669,0.0001368277,0.000178929,0.0001617133,0.0002100767,0.001652917],"category_scores_gemma":[0.00006036301,0.00009395648,0.0002316643,0.0001182097,0.0002091563,0.0001518692,0.0001263538,0.000600539,0.0004962566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003115756,"about_ca_system_score_gemma":0.0002420461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001106612,"about_ca_topic_score_gemma":0.002349449,"domain_scores_codex":[0.9998729,0.0000143034,0.00001083692,0.00001779642,0.00004405084,0.0000400066],"domain_scores_gemma":[0.9999512,0.00001263841,0.00001390591,0.000006418245,0.000004091218,0.00001164272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000461803,0.00005018119,0.00005483518,0.0000227038,0.000003908013,0.00001585823,0.000007127177,0.0000668352,0.9981304,0.0001164513,0.0001149631,0.001370601],"study_design_scores_gemma":[0.0000138091,0.0002141509,0.0009748974,0.00000296041,0.000005827063,0.00007595492,0.000005433321,0.000925608,0.9961889,0.00002895734,0.001561925,0.000001543856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850886,0.002700989,0.006197421,0.0002546324,0.00007999864,0.00005513701,0.001266278,0.0003411357,0.004015768],"genre_scores_gemma":[0.9885981,0.001216262,0.003323756,0.00007694694,0.00001442489,0.00005043831,0.001593594,0.00003495762,0.005091548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001652917,"threshold_uncertainty_score":0.005529583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04974931770559396,"score_gpt":0.3427876050990504,"score_spread":0.2930382873934565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}