{"id":"W2173203512","doi":"10.1093/nar/gkv1261","title":"Foreign DNA acquisition by the I-F CRISPR–Cas system requires all components of the interference machinery","year":2015,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Russian Science Foundation; National Institutes of Health; Russian Foundation for Basic Research","keywords":"CRISPR; Biology; DNA; Priming (agriculture); Trans-activating crRNA; RNA; Adaptation (eye); Computational biology; CRISPR interference; Genetics; Cas9; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001759728,0.0003920898,0.0004426816,0.0001471375,0.0002261918,0.0004107179,0.0003066182,0.0004255615,0.0008081853],"category_scores_gemma":[0.0002931081,0.000244398,0.0003219813,0.0001662276,0.0003241477,0.0003658613,0.0002619217,0.0006883272,0.0003536902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004034566,"about_ca_system_score_gemma":0.0003061336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006412092,"about_ca_topic_score_gemma":0.0007500362,"domain_scores_codex":[0.9996643,0.00003621186,0.00003087791,0.000108957,0.00009900598,0.00006067775],"domain_scores_gemma":[0.9997591,0.00006157621,0.00006324022,0.00005909428,0.0000228285,0.00003406944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003678312,0.00001779622,0.000350948,0.00001676491,0.000003514748,0.00004257592,0.00001104691,0.0001094183,0.9980571,0.0001804793,0.00002633878,0.001147241],"study_design_scores_gemma":[0.000005204014,0.000114244,0.0031725,0.000002299659,0.000004883993,0.0003133769,0.00001375309,0.001380197,0.9937655,0.0001307109,0.001087264,0.00001008756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9624755,0.0006211343,0.03297888,0.00007062696,0.0000341635,0.00007403563,0.0003300201,0.0003173076,0.003098319],"genre_scores_gemma":[0.9722824,0.0003867711,0.02459519,0.00006201042,0.000008672817,0.00006169678,0.0004900867,0.00005098513,0.002062279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008081853,"threshold_uncertainty_score":0.002927363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05124137287250299,"score_gpt":0.3625482874433394,"score_spread":0.3113069145708364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}