{"id":"W2173203512","doi":"10.1093/nar/gkv1261","title":"Foreign DNA acquisition by the I-F CRISPR–Cas system requires all components of the interference machinery","year":2015,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Russian Science Foundation; National Institutes of Health; Russian Foundation for Basic Research","keywords":"CRISPR; Biology; DNA; Priming (agriculture); Trans-activating crRNA; RNA; Adaptation (eye); Computational biology; CRISPR interference; Genetics; Cas9; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009120782,0.0001126767,0.000113786,0.00003646057,0.000106014,0.00003528831,0.0006752429,0.0001075928,0.000006289222],"category_scores_gemma":[0.0001179111,0.00006822828,0.00007150743,0.0001380873,0.0002054879,0.000004573774,0.0004827222,0.0002152395,0.0000240759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004718706,"about_ca_system_score_gemma":0.00004401604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001863894,"about_ca_topic_score_gemma":0.00001349524,"domain_scores_codex":[0.9985628,0.0002393481,0.0002030426,0.0002339591,0.0004537635,0.0003070495],"domain_scores_gemma":[0.9990133,0.0000340384,0.00004371592,0.0006071332,0.0002100387,0.00009179246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009834317,0.00003473036,0.001521697,0.00005616623,0.00004231118,0.000001374655,0.0002129485,0.0001004327,0.9711289,0.0003738131,0.02571157,0.0007177047],"study_design_scores_gemma":[0.0007027735,0.0004388748,0.00710117,0.0001128241,0.0000182991,0.00004891978,0.001932273,0.00313727,0.9711707,0.0002292507,0.01491781,0.0001898308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893709,0.00108782,0.003692367,0.0003613321,0.0001553729,0.0002932098,0.00003675866,0.00001319543,0.004989013],"genre_scores_gemma":[0.9991642,0.00003767798,0.00007938204,0.0000564403,0.0001259399,0.00002356099,0.00004395508,0.00002103304,0.0004478389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01079375,"threshold_uncertainty_score":0.2782269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05124137287250299,"score_gpt":0.3625482874433394,"score_spread":0.3113069145708364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}