{"id":"W2173237260","doi":"10.1002/pro.2845","title":"Distribution of single‐nucleotide variants on protein–protein interaction sites and its relationship with minor allele frequency","year":2015,"lang":"en","type":"article","venue":"Protein Science","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"","keywords":"Minor allele frequency; Genetics; Allele frequency; Minor (academic); Allele; Biology; Single-nucleotide polymorphism; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008170044,0.0001161708,0.0001257831,0.00005345044,0.0001500975,0.00002647725,0.0001637235,0.00009064534,0.000004152661],"category_scores_gemma":[0.001978167,0.00009678882,0.00002095878,0.0002513693,0.0002237326,0.00002546759,0.00007305944,0.00008683775,0.00000787089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005192305,"about_ca_system_score_gemma":0.0001930343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006622454,"about_ca_topic_score_gemma":0.00004407241,"domain_scores_codex":[0.9988315,0.0001072045,0.0002272603,0.0003812761,0.000220665,0.0002320557],"domain_scores_gemma":[0.9990705,0.00001595782,0.000221764,0.0002225684,0.0003555626,0.0001136164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006205187,0.00007389314,0.01298366,0.00001210212,0.000006934327,6.557063e-7,0.00005693964,0.00005329742,0.9842339,0.002095303,0.00003880429,0.0003824225],"study_design_scores_gemma":[0.0008548168,0.002804861,0.1603668,0.0001221212,0.00001673032,0.00001601066,0.0001978563,0.0006679955,0.8292639,0.004723293,0.0006104472,0.0003552229],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958519,0.0001446935,0.002198012,0.0004591663,0.00002731906,0.000631225,0.00001737872,0.000009721384,0.0006605384],"genre_scores_gemma":[0.9950545,0.000001879892,0.00441433,0.00002600412,0.00004999771,0.00008881436,0.0000519708,0.000007734332,0.0003046995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.15497,"threshold_uncertainty_score":0.3946933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04239761867273373,"score_gpt":0.2819306153867661,"score_spread":0.2395329967140323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}