{"id":"W2173237260","doi":"10.1002/pro.2845","title":"Distribution of single‐nucleotide variants on protein–protein interaction sites and its relationship with minor allele frequency","year":2015,"lang":"en","type":"article","venue":"Protein Science","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"","keywords":"Minor allele frequency; Genetics; Allele frequency; Minor (academic); Allele; Biology; Single-nucleotide polymorphism; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001222397,0.0002124396,0.0003250163,0.001844359,0.0002977432,0.0005362396,0.0002660039,0.0005163522,0.002210484],"category_scores_gemma":[0.00456176,0.0001640914,0.0003316809,0.001160458,0.0005219824,0.0002988848,0.0003285367,0.0005186764,0.0002743937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001150687,"about_ca_system_score_gemma":0.00008166451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005748678,"about_ca_topic_score_gemma":0.0004663792,"domain_scores_codex":[0.9985752,0.0004732457,0.0001832465,0.0004618372,0.0001888666,0.0001176048],"domain_scores_gemma":[0.9945858,0.002821969,0.00133535,0.0005346218,0.0003423399,0.000379933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006220247,0.00004242036,0.9666417,0.00003583805,0.0003436569,0.0005901825,0.0001838942,0.0002859754,0.01790906,0.0004671853,0.0001148712,0.01276322],"study_design_scores_gemma":[0.00001030559,0.0001583321,0.9911936,0.00000866733,0.0001217579,0.002855067,0.000150863,0.001549824,0.00226735,0.0009539675,0.0007103744,0.00001989823],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995697,0.0006976397,0.002570638,0.00004419491,0.00001066939,0.000008996327,0.000230229,0.00002251789,0.0007180742],"genre_scores_gemma":[0.9990917,0.0001015038,0.0005225827,0.000009797192,0.000009665069,0.000005964047,0.0001160123,0.000006309102,0.0001364063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002210484,"threshold_uncertainty_score":0.00739485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04239761867273373,"score_gpt":0.2819306153867661,"score_spread":0.2395329967140323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}