{"id":"W2173326641","doi":"10.1081/ncn-120026634","title":"<i>Cyclo</i>Saligenyl Pronucleotides of 5-Iodo and 5-Trifluoromethyl-1-(2-deoxy-β-<scp>D</scp>-ribofuranosyl)-2,4-difluorobenzene Mimics of Thymidine: Synthesis and Evaluation of this Pronucleotide Monophosphate Delivery System for Compounds with Potential Anticancer Activity","year":2003,"lang":"en","type":"article","venue":"Nucleosides Nucleotides & Nucleic Acids","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Diastereomer; Stereochemistry; Substituent; Chemistry; Trifluoromethyl; Thymidine; In vitro; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001802517,0.0006352003,0.001135609,0.0002418909,0.0002310589,0.00006931665,0.0004661181,0.0004557333,0.00001516852],"category_scores_gemma":[0.000969096,0.0005728522,0.0003158493,0.0004088665,0.001153377,0.00007270085,0.0002872466,0.0002524376,0.000001442356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007928199,"about_ca_system_score_gemma":0.0002871039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001621876,"about_ca_topic_score_gemma":0.00002342088,"domain_scores_codex":[0.9957446,0.0004875768,0.0009517178,0.001079747,0.0009910796,0.0007452682],"domain_scores_gemma":[0.9966313,0.000341177,0.0008016378,0.0008517693,0.001069056,0.0003050498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007539761,0.0003964225,0.004437829,0.001520861,0.0006406279,0.000003814675,0.0001659793,0.000104781,0.9832525,0.0005999153,0.0002789618,0.00784428],"study_design_scores_gemma":[0.002363946,0.001202425,0.007999229,0.0004285043,0.0008379141,0.00006093745,0.0006295412,0.001510814,0.9837338,0.0001844587,0.0006911422,0.0003572722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927529,0.003560524,0.0005629265,0.00006033894,0.0001038875,0.001862579,0.0002369415,0.00004373355,0.0008161829],"genre_scores_gemma":[0.9881777,0.001050279,0.0103085,0.00003273278,0.00005906817,0.0001392752,0.00003327982,0.0001642091,0.00003497231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009745576,"threshold_uncertainty_score":0.9996723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01227741570135653,"score_gpt":0.2440015017879634,"score_spread":0.2317240860866069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}