{"id":"W2173390962","doi":"10.1089/108729002321082438","title":"Antitumor Effect of G3139 Bcl-2 Antisense Oligonucleotide Is Independent of Its Immune Stimulation by CpG Motifs in SCID Mice","year":2002,"lang":"en","type":"article","venue":"Antisense and Nucleic Acid Drug Development","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Oesterreichische Nationalbank; Austrian Science Fund","keywords":"Biology; Immune system; Stimulation; Methylation; Apoptosis; CpG site; Oligonucleotide; Molecular biology; DNA methylation; Immunology; Endocrinology; Gene expression; DNA; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003027355,0.0002609993,0.0004115426,0.0001428569,0.00007096285,0.00001723932,0.0001614433,0.0001316496,0.00008923614],"category_scores_gemma":[0.00004179071,0.0002443463,0.00008436723,0.0001588389,0.00009122206,0.00001878326,0.0001612747,0.000100341,0.00003941888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001590694,"about_ca_system_score_gemma":0.0000402426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004693269,"about_ca_topic_score_gemma":0.00002036925,"domain_scores_codex":[0.9983597,0.00008973566,0.0006001264,0.0004303469,0.0002314294,0.0002886349],"domain_scores_gemma":[0.999316,0.0000227111,0.000222538,0.0002547336,0.0001090126,0.00007496095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001494625,0.0001310598,0.01376913,0.0001393056,0.00008544252,0.00002082102,0.0005568332,0.00001675214,0.9754617,0.000003522163,0.00240078,0.007265195],"study_design_scores_gemma":[0.001265865,0.0002503855,0.02296489,0.0001747011,0.00002466632,0.00002485707,0.00007495693,0.0004829862,0.9732986,0.000002380039,0.001177366,0.0002583172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945705,0.004664262,0.00003966095,0.0000803677,0.0001081926,0.0002912354,0.00002900022,0.000008288346,0.0002085127],"genre_scores_gemma":[0.9957947,0.003241222,0.0002029136,0.00009709589,0.00002148268,0.000008419513,0.00006218716,0.00002454341,0.0005473994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009195761,"threshold_uncertainty_score":0.9964154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0062783922109265,"score_gpt":0.2164001993243996,"score_spread":0.2101218071134731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}