{"id":"W2173390962","doi":"10.1089/108729002321082438","title":"Antitumor Effect of G3139 Bcl-2 Antisense Oligonucleotide Is Independent of Its Immune Stimulation by CpG Motifs in SCID Mice","year":2002,"lang":"en","type":"article","venue":"Antisense and Nucleic Acid Drug Development","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Oesterreichische Nationalbank; Austrian Science Fund","keywords":"Biology; Immune system; Stimulation; Methylation; Apoptosis; CpG site; Oligonucleotide; Molecular biology; DNA methylation; Immunology; Endocrinology; Gene expression; DNA; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002433725,0.0008725463,0.0004773622,0.0007552034,0.0002290347,0.0003063844,0.0003203636,0.0007856165,0.002157418],"category_scores_gemma":[0.0001300421,0.000305797,0.000436141,0.0002563078,0.0004420309,0.0003005622,0.0001798849,0.001306853,0.000550165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003128239,"about_ca_system_score_gemma":0.0003721458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006198661,"about_ca_topic_score_gemma":0.0008043131,"domain_scores_codex":[0.9996926,0.0000473914,0.00003605227,0.00007149741,0.00007201915,0.00008044913],"domain_scores_gemma":[0.9997554,0.00002856616,0.00008991668,0.00003303849,0.00001544414,0.00007761118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004560226,0.0001955977,0.00007539562,0.0000275658,0.000006252767,0.00004507203,0.00001021093,0.00006144358,0.9980357,0.00009987762,0.00004083063,0.0009458601],"study_design_scores_gemma":[0.0003018977,0.004712288,0.002282488,0.00001212435,0.00003099315,0.0002864909,0.00001885742,0.001139475,0.9894539,0.00008550376,0.00166787,0.000008131014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950134,0.0007679691,0.001205931,0.0001929562,0.00005957802,0.0001045747,0.0006369712,0.0002506083,0.001767993],"genre_scores_gemma":[0.9910739,0.0008943735,0.001842842,0.0001649446,0.00003347913,0.0001969601,0.001065671,0.00004722936,0.004680648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002157418,"threshold_uncertainty_score":0.007217288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0062783922109265,"score_gpt":0.2164001993243996,"score_spread":0.2101218071134731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}