{"id":"W2173459804","doi":"10.1016/s0223-5234(00)00124-0","title":"N-Butyl-N-methyl-11-(3'-hydroxy-21',17'-carbolactone-19'-nor-17'α-pregna-1',3',5'(10')-trien-7'α-yl)-undecanamide: an inhibitor of type 2 17β-hydroxysteroid dehydrogenase that does not have oestrogenic or androgenic activity","year":2000,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval","funders":"Medical Research Council Canada","keywords":"Chemistry; Androgen; Stereochemistry; Cell growth; Steroid; Lactone; Microsome; Hydroxysteroid dehydrogenase; Enzyme; Cell culture; Testosterone (patch); Dehydrogenase; Biological activity; Biochemistry; IC50; Moiety; In vitro; Endocrinology; Hormone; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001072943,0.0002991388,0.0003080472,0.0001710947,0.0002039928,0.0002012871,0.0005137059,0.0002499293,0.004666418],"category_scores_gemma":[0.0001367539,0.0001284247,0.0001092691,0.000133949,0.0001811768,0.0003078511,0.0001521157,0.0003897985,0.002032211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003035757,"about_ca_system_score_gemma":0.000758485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001932634,"about_ca_topic_score_gemma":0.002151978,"domain_scores_codex":[0.9999156,0.000007213348,0.000005399422,0.00001572727,0.0000177209,0.00003827162],"domain_scores_gemma":[0.9999254,0.00001094,0.00001439879,0.00001073374,0.000009417982,0.00002905051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001327023,0.0002090236,0.0002443831,0.0001466414,0.00001805674,0.0002936709,0.00002728604,0.0003775065,0.9763777,0.001263246,0.0007053752,0.01901016],"study_design_scores_gemma":[0.0002325714,0.001132139,0.001903131,0.000009739098,0.00002788783,0.0007084913,0.00002687854,0.0006001928,0.9728764,0.000130279,0.02233688,0.00001552486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9196721,0.009014467,0.01131687,0.0006166279,0.0004663096,0.0002635421,0.001660212,0.000623344,0.05636646],"genre_scores_gemma":[0.9677747,0.003822426,0.002725746,0.0002077152,0.00006230463,0.00008534587,0.001390862,0.00003914215,0.0238919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004666418,"threshold_uncertainty_score":0.01561069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01370818409004534,"score_gpt":0.2561581767318262,"score_spread":0.2424499926417809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}