{"id":"W2173459804","doi":"10.1016/s0223-5234(00)00124-0","title":"N-Butyl-N-methyl-11-(3'-hydroxy-21',17'-carbolactone-19'-nor-17'α-pregna-1',3',5'(10')-trien-7'α-yl)-undecanamide: an inhibitor of type 2 17β-hydroxysteroid dehydrogenase that does not have oestrogenic or androgenic activity","year":2000,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval","funders":"Medical Research Council Canada","keywords":"Chemistry; Androgen; Stereochemistry; Cell growth; Steroid; Lactone; Microsome; Hydroxysteroid dehydrogenase; Enzyme; Cell culture; Testosterone (patch); Dehydrogenase; Biological activity; Biochemistry; IC50; Moiety; In vitro; Endocrinology; Hormone; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001522383,0.000731885,0.0009431034,0.0001161228,0.0001915317,0.00006931974,0.001026481,0.0004236699,0.0009643505],"category_scores_gemma":[0.0003113549,0.0005267326,0.0005481766,0.0003037902,0.000512906,0.00006419875,0.0001697945,0.0009637646,0.00002148649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000113551,"about_ca_system_score_gemma":0.0005417361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002544193,"about_ca_topic_score_gemma":0.00001000732,"domain_scores_codex":[0.9956016,0.0007018695,0.001160442,0.0007808405,0.0009681272,0.0007871232],"domain_scores_gemma":[0.9964392,0.0001034163,0.001071647,0.0009483987,0.0003064723,0.001130823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004098518,0.0004639577,0.0008874245,0.0001585479,0.0005582107,0.0009740436,0.0001538593,0.0001361455,0.9828606,2.949422e-7,0.00532095,0.004387448],"study_design_scores_gemma":[0.004142643,0.0024598,0.0001812872,0.0003159237,0.0004438934,0.002153031,0.0002123198,0.0001297734,0.9687265,0.000004124538,0.02062569,0.0006050797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917092,0.005027777,0.00006050531,0.0001884115,0.0002478741,0.0002503603,0.0001169299,0.00003202598,0.002366918],"genre_scores_gemma":[0.9882427,0.001375444,0.0001437618,0.000248211,0.001090328,0.000003813843,0.0001442954,0.0001450123,0.008606385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01530474,"threshold_uncertainty_score":0.9999489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01370818409004534,"score_gpt":0.2561581767318262,"score_spread":0.2424499926417809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}