{"id":"W2173518829","doi":"10.1038/mt.2015.185","title":"Gene Editing and Germ-line Intervention: The Need for Novel Responses to Novel Technologies","year":2015,"lang":"en","type":"letter","venue":"Molecular Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Wellcome Trust","keywords":"CRISPR; Scopus; Genome editing; Germline; Genetics; Gene; Biology; Political science; MEDLINE; Law","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000333918,0.0003351788,0.0002581956,0.0001034387,0.00008394371,0.00007444195,0.0004128545,0.0005503332,0.000002591347],"category_scores_gemma":[0.0002087246,0.0002645743,0.0001861923,0.0001008555,0.00008134,0.000002047334,0.0001995195,0.0003321054,0.000002123473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001627907,"about_ca_system_score_gemma":0.00004122907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008653957,"about_ca_topic_score_gemma":0.000003174478,"domain_scores_codex":[0.9986852,0.00002818364,0.0002604836,0.0004981488,0.0001812832,0.000346744],"domain_scores_gemma":[0.9990516,0.00003191333,0.00009691204,0.0006140952,0.0001661605,0.00003929068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001264709,0.00003010951,0.000004307038,0.00003677465,0.0001712253,0.000009445851,0.00003980621,0.00008923679,0.9015208,0.000007846218,0.08865343,0.009310506],"study_design_scores_gemma":[0.0008663326,0.000336903,0.000007903302,0.00002719499,0.00002076864,0.00004058891,0.00005471033,0.00004534665,0.4232285,0.00004602154,0.575097,0.0002286873],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"commentary","genre_scores_codex":[0.07226695,0.01665714,0.6470152,0.261519,0.0007083543,0.001376876,0.0003078266,0.000111558,0.00003705369],"genre_scores_gemma":[0.2700888,0.002029788,0.07776407,0.6212611,0.01417993,0.002549991,0.003312027,0.0008829344,0.007931351],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.5692512,"threshold_uncertainty_score":0.9999806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02531575537985657,"score_gpt":0.3213336571325398,"score_spread":0.2960179017526832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}