{"id":"W2173601762","doi":"10.1212/wnl.0000000000001991","title":"Detailed comparison of amyloid PET and CSF biomarkers for identifying early Alzheimer disease","year":2015,"lang":"en","type":"article","venue":"Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":387,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Canadian Institutes of Health Research","keywords":"Biomarker; Medicine; Dementia; Internal medicine; Alzheimer's disease; Posterior cingulate; Cerebrospinal fluid; Oncology; Precuneus; Amyloid (mycology); Neuroimaging; Pathology; Positron emission tomography; Disease; Nuclear medicine; Cognition; Psychiatry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004935804,0.0008030403,0.0007193595,0.001523219,0.0002212621,0.0009753141,0.0002148882,0.000720482,0.0005328623],"category_scores_gemma":[0.01226633,0.000360704,0.0004192598,0.0005641895,0.0002971672,0.0006691358,0.0002843113,0.0002651016,0.000231363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002583688,"about_ca_system_score_gemma":0.0002518938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000753299,"about_ca_topic_score_gemma":0.0009335419,"domain_scores_codex":[0.9986595,0.0006638809,0.0001643499,0.0002141348,0.0002181844,0.00007981788],"domain_scores_gemma":[0.9952593,0.002887271,0.0006281137,0.0003015894,0.0007306966,0.0001929662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005627938,0.0001266311,0.9544625,0.0001161055,0.0006628625,0.0003877241,0.000125338,0.00125724,0.009166291,0.00004953107,0.0002096437,0.02780801],"study_design_scores_gemma":[0.0002097532,0.00187513,0.9850033,0.00005398896,0.0004411881,0.002330719,0.00009584837,0.004410124,0.004624882,0.0002192234,0.0007075826,0.00002823182],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958548,0.002986164,0.0006585582,0.00003724816,0.0000112168,0.00001811709,0.0001532352,0.00001657265,0.0002641941],"genre_scores_gemma":[0.9984687,0.0003384849,0.000784745,0.00002213171,0.0000199141,0.00001186552,0.0002691426,0.000004854538,0.00008017321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004935804,"threshold_uncertainty_score":0.02610332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09162103567271467,"score_gpt":0.3865764856237572,"score_spread":0.2949554499510425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}