{"id":"W2173616003","doi":"10.1016/j.bmcl.2007.06.012","title":"Thiotetrazole alkynylacetanilides as potent and bioavailable non-nucleoside inhibitors of the HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; Mutant; Bioavailability; Nucleoside; Enzyme; Enzyme inhibitor; Nucleotidyltransferase; Stereochemistry; Biochemistry; Pharmacology; RNA; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003683698,0.0003259239,0.0004376164,0.00006250702,0.0001398873,0.00001651422,0.0001306324,0.0001484154,0.0002186853],"category_scores_gemma":[0.00008500066,0.0002230556,0.00008061157,0.0004160421,0.0004477916,0.00006971371,0.00006522964,0.0003007096,0.00002243336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001383889,"about_ca_system_score_gemma":0.0001764261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001189946,"about_ca_topic_score_gemma":0.0000102484,"domain_scores_codex":[0.9981682,0.00001353445,0.0004689463,0.0004255209,0.0005119325,0.000411897],"domain_scores_gemma":[0.9990624,0.000059958,0.0001490491,0.0003469487,0.00008524936,0.0002964462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004333074,0.0001139133,0.01571729,0.0003086666,0.0001760463,0.0002386201,0.0009527068,1.422504e-7,0.9691282,0.000002686361,0.0124292,0.0004992124],"study_design_scores_gemma":[0.003485627,0.0000738927,0.007394999,0.0005614467,0.0004387011,0.0006446376,0.001657758,0.000004752143,0.9735076,0.000003482456,0.0119972,0.0002299206],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978004,0.001345767,0.00001373714,0.0190845,0.0001902929,0.000374719,0.00001199993,0.00004064541,0.0009342859],"genre_scores_gemma":[0.9953573,0.0003068034,0.0002981824,0.001695209,0.0001906692,0.000003890352,0.00003043081,0.0000360298,0.002081479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01738929,"threshold_uncertainty_score":0.9095944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007492722331657846,"score_gpt":0.2186762261624015,"score_spread":0.2111835038307436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}