{"id":"W2173702989","doi":"10.1016/j.biologicals.2015.09.001","title":"Reverse vaccinology as an approach for developing Histophilus somni vaccine candidates","year":2015,"lang":"en","type":"article","venue":"Biologicals","topic":"Microbial infections and disease research","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Health; University of Saskatchewan","funders":"Alberta Livestock and Meat Agency","keywords":"Reverse vaccinology; Biology; Genome; Antigen; Antigenicity; Microbiology; Bacteria; Whole genome sequencing; Pathogen; Vaccination; Gene; Virology; Computational biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004276983,0.0001888566,0.0003447438,0.0001235237,0.0002084061,0.00002123186,0.000267295,0.0004238306,0.0004635906],"category_scores_gemma":[0.0005208771,0.0001356404,0.00009457788,0.0001478686,0.0000884036,0.00008251254,0.000128959,0.0001686884,0.0005623993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001261585,"about_ca_system_score_gemma":0.0003606693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005812581,"about_ca_topic_score_gemma":0.00002366451,"domain_scores_codex":[0.9984809,0.0002444181,0.0002776753,0.0004669925,0.00002220167,0.0005078607],"domain_scores_gemma":[0.999222,0.0001082877,0.00008234975,0.0002909767,0.0001744665,0.0001218807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002375263,0.0008364717,0.00690027,0.00005041157,0.0003388113,0.00001357272,0.0002476852,0.00002620198,0.6334353,0.04547705,0.2988113,0.01148764],"study_design_scores_gemma":[0.007886972,0.002660384,0.002989511,0.00001905748,0.00009638051,0.0004198125,0.0004889776,0.00004223553,0.07073018,0.02189513,0.8918457,0.0009256465],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.971967,0.00664833,0.01307004,0.00211188,0.0008948694,0.001380359,0.0001440074,0.0003751403,0.003408329],"genre_scores_gemma":[0.9860288,0.000163006,0.004689952,0.0009544967,0.0002002631,0.0001286313,0.001225778,0.00001934246,0.006589735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5930344,"threshold_uncertainty_score":0.7228693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08899190730983174,"score_gpt":0.3403462491360139,"score_spread":0.2513543418261822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}