{"id":"W2173802285","doi":"10.1016/j.stemcr.2015.10.014","title":"Metformin Acts on Two Different Molecular Pathways to Enhance Adult Neural Precursor Proliferation/Self-Renewal and Differentiation","year":2015,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa; Hospital for Sick Children; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Biology; Neural stem cell; Metformin; Cellular differentiation; Stem cell; AMPK; Cell biology; Neural development; Population; Neuroscience; Endocrinology; Diabetes mellitus; Genetics; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001454134,0.0003467269,0.0003049481,0.0001334783,0.0001439346,0.0001657588,0.0001377584,0.0000643925,0.000005430557],"category_scores_gemma":[0.0002170427,0.0002871577,0.00007303242,0.0001841388,0.00002063834,0.0001652344,0.0001384109,0.0001473004,0.00002587202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005701786,"about_ca_system_score_gemma":0.00005881654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002857789,"about_ca_topic_score_gemma":0.00000752733,"domain_scores_codex":[0.997125,0.0002297007,0.0005058639,0.0009677153,0.0007710356,0.0004006549],"domain_scores_gemma":[0.9985133,0.0001166767,0.0002996274,0.0004819087,0.0001135725,0.0004748909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008122419,0.0002616336,0.0002471585,0.00003146119,0.000003532692,0.0006624968,0.0003365984,0.0001746484,0.9960703,0.001139718,0.00003729075,0.0009539692],"study_design_scores_gemma":[0.0002973537,0.0007317125,0.0001313124,0.00002377468,0.00003028303,0.000229141,0.00001740917,0.00111209,0.9968047,0.0002451185,0.00009815563,0.0002789428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959805,0.00002099123,0.000894413,0.0000695385,0.001004048,0.0009337297,0.00000833342,0.0001804149,0.0009080207],"genre_scores_gemma":[0.9986726,0.00001245084,0.00009193808,0.0007180494,0.00007801441,0.0001237665,0.0000043288,0.00005108719,0.0002477552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002692098,"threshold_uncertainty_score":0.999958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02519547974694305,"score_gpt":0.2536732198739072,"score_spread":0.2284777401269641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}