{"id":"W2173922215","doi":"10.1371/journal.pone.0142296","title":"TDP-43 Inhibits NF-κB Activity by Blocking p65 Nuclear Translocation","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Fondation pour la Recherche sur Alzheimer","keywords":"Transactivation; Heterogeneous nuclear ribonucleoprotein; Nuclear transport; Nuclear localization sequence; Cell biology; Chromosomal translocation; Nuclear export signal; Nuclear protein; Cell nucleus; Importin; IκBα; Biology; NF-κB; Chemistry; Transcription factor; Signal transduction; Ribonucleoprotein; Cytoplasm; Gene; Biochemistry; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002072428,0.0001403627,0.0001523314,0.00002741402,0.00006287453,0.00002776082,0.000147882,0.0001690338,0.00001603959],"category_scores_gemma":[0.00008169719,0.0001548426,0.00004537528,0.00008133711,0.00004555145,0.000007090233,0.00004950275,0.0001217501,0.00006251479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000273909,"about_ca_system_score_gemma":0.00006555387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003034775,"about_ca_topic_score_gemma":0.00001399321,"domain_scores_codex":[0.9989968,0.00006168072,0.0001373043,0.0003260452,0.0002551907,0.0002230098],"domain_scores_gemma":[0.9993629,0.000007311844,0.00007083974,0.000306286,0.000119606,0.0001329836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006664925,0.0005484438,0.0002480191,0.00002314136,0.00007658016,0.00000115078,0.0001514958,0.00001316639,0.9965557,0.00001965075,0.00128284,0.001013159],"study_design_scores_gemma":[0.0005675198,0.0001966539,0.00003152193,0.0000482947,0.00003831745,0.000002287101,0.00002612469,0.0002685322,0.9961125,0.00004074344,0.002476204,0.0001912712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997124,0.0004545228,0.0003965865,0.0003009216,0.00004055099,0.0001692788,0.0000267839,0.00004954544,0.001437832],"genre_scores_gemma":[0.9981433,0.0000457449,0.0009092993,0.0002119787,0.0002064186,0.00001301843,0.00008012557,0.00004187227,0.0003482335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001193364,"threshold_uncertainty_score":0.63143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0551774340542397,"score_gpt":0.2250463533369685,"score_spread":0.1698689192827288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}