{"id":"W2173922215","doi":"10.1371/journal.pone.0142296","title":"TDP-43 Inhibits NF-κB Activity by Blocking p65 Nuclear Translocation","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Fondation pour la Recherche sur Alzheimer","keywords":"Transactivation; Heterogeneous nuclear ribonucleoprotein; Nuclear transport; Nuclear localization sequence; Cell biology; Chromosomal translocation; Nuclear export signal; Nuclear protein; Cell nucleus; Importin; IκBα; Biology; NF-κB; Chemistry; Transcription factor; Signal transduction; Ribonucleoprotein; Cytoplasm; Gene; Biochemistry; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001580944,0.0004110303,0.000437041,0.0002046901,0.0001803242,0.0002280481,0.0002547153,0.0002836039,0.001105771],"category_scores_gemma":[0.0001090997,0.0001590047,0.0004110462,0.0001875582,0.0002817962,0.0002208911,0.0001848304,0.0008815726,0.0003263947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002244662,"about_ca_system_score_gemma":0.0003208361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005769119,"about_ca_topic_score_gemma":0.000592954,"domain_scores_codex":[0.9998451,0.00002377609,0.00001994047,0.00003167466,0.00003607067,0.00004341391],"domain_scores_gemma":[0.9999182,0.00001871617,0.00001864617,0.00001119342,0.00001000055,0.00002324625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001781849,0.0001208675,0.00005401904,0.000103532,0.000009390684,0.00004538144,0.00001721825,0.00006536822,0.9978079,0.00006838494,0.00005930494,0.001470453],"study_design_scores_gemma":[0.00004233872,0.0008621746,0.001239328,0.000008433057,0.00002005306,0.0001739545,0.0000167048,0.0007608326,0.9944787,0.00005126993,0.002341772,0.00000450388],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984001,0.007437016,0.005615069,0.0002549214,0.0001676887,0.00004878615,0.0002657512,0.0003080117,0.00190174],"genre_scores_gemma":[0.9906747,0.004002116,0.002703365,0.00007432706,0.00003448364,0.00007053895,0.0003876756,0.00002634305,0.002026445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001105771,"threshold_uncertainty_score":0.003699243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0551774340542397,"score_gpt":0.2250463533369685,"score_spread":0.1698689192827288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}