{"id":"W2174104590","doi":"10.1007/978-1-4939-0956-8_8","title":"G Protein-Coupled Receptor Mutations and Human Genetic Disease","year":2014,"lang":"en","type":"review","venue":"Methods in molecular biology","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital du Sacré-Cœur de Montréal; University of Toronto; Royal Victoria Hospital; McGill University Health Centre; Surrey Place Centre; McGill University; Canada Research Chairs","funders":"Canadian Institutes of Health Research","keywords":"GNRHR; G protein-coupled receptor; Biology; Melanocortin; Receptor; Endocrinology; Internal medicine; Genetics; Gonadotropin-releasing hormone; Medicine; Hormone; Luteinizing hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007121839,0.001150438,0.001229667,0.001750467,0.000202533,0.0007710914,0.001051885,0.001145199,0.002721112],"category_scores_gemma":[0.0009055608,0.0002853234,0.0003804869,0.001666031,0.000840784,0.001136529,0.0008107071,0.001918564,0.00178421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006890899,"about_ca_system_score_gemma":0.001034845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001028879,"about_ca_topic_score_gemma":0.001714632,"domain_scores_codex":[0.9997844,0.00002702752,0.00003538114,0.00004150471,0.00009086823,0.00002083597],"domain_scores_gemma":[0.9996412,0.0001868573,0.00004261902,0.00001248736,0.00008269267,0.00003405394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007287898,0.00004797884,0.0001591074,0.006270909,0.0000560212,0.0002751455,0.00002459242,0.0003486853,0.001659379,0.004268816,0.03962795,0.9471886],"study_design_scores_gemma":[0.00002421648,0.00003944475,0.0006508244,0.001883643,0.0001030823,0.001485982,0.00002988785,0.0001002725,0.0006661645,0.00368878,0.9913072,0.00002054601],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007748816,0.9980935,0.0003301131,0.0003246235,0.0003489786,0.000003582209,0.00001592167,0.00001055666,0.0007952627],"genre_scores_gemma":[0.0004679843,0.9979316,0.0003248136,0.0002123709,0.000381386,0.000004770627,0.00003208906,0.000002359875,0.0006426986],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002721112,"threshold_uncertainty_score":0.009103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05714460746486543,"score_gpt":0.4389488097936646,"score_spread":0.3818042023287992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}