{"id":"W2174279070","doi":"10.1139/y11-056","title":"Dissociation of the vacuolar and macroautophagic cytopathology from the cytotoxicity induced by the lipophilic local anesthetic bupivacaine","year":2011,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Anesthesia and Neurotoxicity Research","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research","keywords":"Bupivacaine; Cytotoxicity; Vacuolization; Local anesthetic; Vacuole; Pharmacology; Biology; Bafilomycin; Apoptosis; Biochemistry; Autophagy; In vitro; Cytoplasm; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001621,0.0002799466,0.0003052552,0.0002088674,0.0001151612,0.0003329669,0.0001924173,0.0002887884,0.001276255],"category_scores_gemma":[0.0002559459,0.0001379482,0.0002686004,0.000159372,0.0002097967,0.0003398143,0.0002099866,0.000419764,0.0002787054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001793367,"about_ca_system_score_gemma":0.0002468136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005298387,"about_ca_topic_score_gemma":0.0005571842,"domain_scores_codex":[0.9998047,0.00003483149,0.00002434507,0.00002149553,0.0000582561,0.00005646994],"domain_scores_gemma":[0.9997938,0.000056038,0.00004739366,0.00002856733,0.00004572668,0.00002843624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000110641,0.0000110287,0.0001510311,0.00002882327,0.000002532379,0.00003857808,0.00001388245,0.00002593764,0.9988784,0.00003650932,0.000006675825,0.0006959469],"study_design_scores_gemma":[0.00001578198,0.0005451667,0.01890052,0.00001407583,0.00001291292,0.0004614837,0.00006143007,0.0005457498,0.9784684,0.00004312897,0.0009267962,0.000004660444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941564,0.00185431,0.001882813,0.00004883676,0.00001026643,0.00003854065,0.0002653091,0.00003258859,0.001710868],"genre_scores_gemma":[0.9954515,0.001040428,0.001543526,0.00003553069,0.0000102992,0.00007223363,0.0004364212,0.00001515133,0.001394897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001276255,"threshold_uncertainty_score":0.004269481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03844602552513028,"score_gpt":0.2662003878025753,"score_spread":0.2277543622774451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}