{"id":"W2174320978","doi":"10.1139/y11-030","title":"Simulation of differential drug pharmacokinetics under heat and exercise stress using a physiologically based pharmacokinetic modeling approach","year":2011,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Thermoregulation and physiological responses","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Defence Research and Development Canada; University of Waterloo","funders":"Defence Research and Development Canada","keywords":"Pharmacokinetics; Pharmacology; Drug; Medicine; Area under the curve; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000133515,0.0001997881,0.0005607448,0.0002443574,0.0001020393,0.000004270101,0.0001045737,0.0001398139,0.001313088],"category_scores_gemma":[0.00002537435,0.0001529823,0.0001072734,0.0001176382,0.0004382573,0.00006101027,0.00002336271,0.0003139754,4.282585e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002654735,"about_ca_system_score_gemma":0.0002688301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001563871,"about_ca_topic_score_gemma":0.000006282225,"domain_scores_codex":[0.9987248,0.0002615551,0.0004329263,0.0002139228,0.00008285078,0.00028391],"domain_scores_gemma":[0.9988349,0.0001885918,0.0001856817,0.00008005681,0.0002314707,0.0004792876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.003084441,0.000146834,0.0003587655,0.0001672049,0.0001133398,0.00001517596,0.0003132085,0.2052665,0.7898582,0.00002612456,0.00001335233,0.0006369213],"study_design_scores_gemma":[0.003580793,0.0005030615,0.05006696,0.00008666184,0.0006936179,0.00003888975,0.0001118898,0.8534132,0.09060172,0.0006849119,0.00001782465,0.0002004348],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956093,0.000789436,0.003053038,0.00004499166,0.0002110909,0.0002303607,0.00002412479,0.000006747127,0.00003094319],"genre_scores_gemma":[0.9983928,0.0001225468,0.0007688666,0.0005130952,0.0001638542,0.000003082309,0.00001176327,0.00001492383,0.000009066926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6992565,"threshold_uncertainty_score":0.9995999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07246991182065242,"score_gpt":0.3161633557095408,"score_spread":0.2436934438888884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}