{"id":"W2174438161","doi":"10.1053/j.gastro.2015.09.049","title":"Activity of SHIP, Which Prevents Expression of Interleukin 1β, Is Reduced in Patients With Crohn’s Disease","year":2015,"lang":"en","type":"article","venue":"Gastroenterology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"Child and Family Research Institute; BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia","keywords":"Inflammation; Endocrinology; Internal medicine; Lipopolysaccharide; Interleukin; Peripheral blood mononuclear cell; Receptor antagonist; Biology; Immunology; Proinflammatory cytokine; Receptor; Cytokine; Medicine; Antagonist; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001366617,0.0001457918,0.0002380385,0.0000686175,0.000009037394,0.00000279148,0.0002287073,0.00009665589,0.00001759389],"category_scores_gemma":[0.00007298256,0.0001289772,0.00004728834,0.00006663728,0.00009538621,0.00000791394,0.0001616275,0.00009752652,8.836418e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003611009,"about_ca_system_score_gemma":0.00009259974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002695414,"about_ca_topic_score_gemma":0.00005723731,"domain_scores_codex":[0.9988431,0.0001598,0.0002453745,0.0003292551,0.0001733134,0.0002491947],"domain_scores_gemma":[0.9990844,0.000005239583,0.0002286057,0.0003879287,0.0001695683,0.0001243056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009716851,0.0004412296,0.8085002,0.00003554712,0.00003400108,0.000002328038,0.0001106123,0.00007872951,0.1802451,4.926815e-7,0.0006853516,0.0001495088],"study_design_scores_gemma":[0.003256737,0.002061717,0.6943156,0.00009800915,0.00002003307,9.877652e-7,0.00001462978,0.00001491355,0.3000656,0.00002195148,0.0000491592,0.00008068734],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991609,0.00003258228,0.0003005402,0.00005794405,0.0001504849,0.0002046059,0.00006132009,0.000003946816,0.0000276635],"genre_scores_gemma":[0.9994906,0.000003162889,0.0002556425,0.00008589365,0.00003405562,0.0000267915,0.00005181046,0.00001821528,0.00003378233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1198205,"threshold_uncertainty_score":0.5259536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01123210882424052,"score_gpt":0.2482650281493469,"score_spread":0.2370329193251063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}