{"id":"W2174493882","doi":"10.1016/j.bmcl.2004.11.051","title":"Structure–activity relationship studies on ortho-substituted cinnamic acids, a new class of selective EP3 antagonists","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Agonist; Prostaglandin E2 receptor; Stereochemistry; Chemical synthesis; In vivo; Biological activity; Selectivity; Receptor; Structure–activity relationship; In vitro; Pharmacology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002979403,0.0004665952,0.000477888,0.0003071029,0.0001686008,0.0002454399,0.0003571868,0.0002254576,0.003184967],"category_scores_gemma":[0.0002680524,0.0001650626,0.0004028535,0.0003117595,0.0002590239,0.0002434607,0.0001236522,0.0006870669,0.0003397572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002895744,"about_ca_system_score_gemma":0.0002781794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001783482,"about_ca_topic_score_gemma":0.004570181,"domain_scores_codex":[0.9998662,0.00002871743,0.000009153573,0.00001416152,0.00002715636,0.00005445393],"domain_scores_gemma":[0.9998635,0.00003601269,0.00002980928,0.00001458,0.00002071128,0.0000353835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007203215,0.0007848136,0.0005458122,0.0002956823,0.0001174678,0.0002804523,0.00006489793,0.0007942575,0.9721815,0.0003384071,0.0004260234,0.01696734],"study_design_scores_gemma":[0.001912157,0.0445248,0.01843736,0.00003619245,0.0008709837,0.001616145,0.00009043415,0.002406162,0.9137775,0.0002388886,0.01601476,0.00007454278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848863,0.01052253,0.0008051737,0.0001317536,0.00005359678,0.00008959848,0.0006122778,0.00003254308,0.002866126],"genre_scores_gemma":[0.9864915,0.00832522,0.0009367994,0.0001105674,0.00005636409,0.00004518718,0.001000467,0.000009996072,0.003023906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003184967,"threshold_uncertainty_score":0.01065481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01980030757399012,"score_gpt":0.2775610790037536,"score_spread":0.2577607714297635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}