{"id":"W2174508949","doi":"10.1093/nar/gkv1008","title":"Quadruplex formation by both G-rich and C-rich DNA strands of the<i>C9orf72</i>(GGGGCC)8•(GGCCCC)8 repeat: effect of CpG methylation","year":2015,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institutes of Health; Weston Brain Institute","keywords":"Methylation; Biology; CpG site; G-quadruplex; DNA; DNA methylation; Guanine; Epigenetics; Nucleic acid; C9orf72; Trinucleotide repeat expansion; Molecular biology; Stereochemistry; Biochemistry; Genetics; Gene; Chemistry; Nucleotide; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001974111,0.000299421,0.0001815091,0.0001265798,0.0001256993,0.0001627212,0.0001920617,0.0002377416,0.001839091],"category_scores_gemma":[0.0002989698,0.0001649877,0.0001817956,0.00007066454,0.0002012771,0.0001330937,0.0001372507,0.0002635563,0.0003320913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001708716,"about_ca_system_score_gemma":0.0001003988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000484479,"about_ca_topic_score_gemma":0.0006463548,"domain_scores_codex":[0.9997948,0.00005763335,0.00001671321,0.00005921226,0.00003354045,0.00003820953],"domain_scores_gemma":[0.9996654,0.00008829547,0.0001035929,0.00002651111,0.00003115697,0.00008519171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002003599,0.00001518224,0.0001522866,0.00001988319,0.00001013497,0.00002300849,0.0000145891,0.0000532352,0.9988907,0.00001750023,0.00002357639,0.0005795993],"study_design_scores_gemma":[0.00001613952,0.0005633264,0.003982134,0.000005594588,0.00001872346,0.0001551376,0.00001157254,0.0006670024,0.9938403,0.00002579668,0.0007076844,0.000006513012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983532,0.0002977884,0.0005081876,0.00002241857,0.00001058812,0.00001381937,0.000112316,0.00004415246,0.0006374782],"genre_scores_gemma":[0.9980155,0.00009674332,0.0008950183,0.00002730801,0.000006271673,0.00001519786,0.0002435297,0.00002170666,0.0006786691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001839091,"threshold_uncertainty_score":0.006152391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04372595349444621,"score_gpt":0.3564064783278312,"score_spread":0.312680524833385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}