{"id":"W2174508949","doi":"10.1093/nar/gkv1008","title":"Quadruplex formation by both G-rich and C-rich DNA strands of the<i>C9orf72</i>(GGGGCC)8•(GGCCCC)8 repeat: effect of CpG methylation","year":2015,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institutes of Health; Weston Brain Institute","keywords":"Methylation; Biology; CpG site; G-quadruplex; DNA; DNA methylation; Guanine; Epigenetics; Nucleic acid; C9orf72; Trinucleotide repeat expansion; Molecular biology; Stereochemistry; Biochemistry; Genetics; Gene; Chemistry; Nucleotide; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00329562,0.0001888182,0.0004736884,0.0002712011,0.0001333935,0.00002967345,0.0003287543,0.0001920173,0.0001140462],"category_scores_gemma":[0.001369334,0.0001297946,0.0001231457,0.001083699,0.0004928168,0.0001576997,0.00025081,0.0005632536,0.00001306228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007501137,"about_ca_system_score_gemma":0.0002351966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001324594,"about_ca_topic_score_gemma":0.00001037622,"domain_scores_codex":[0.9955624,0.0009366231,0.0004901743,0.0003714412,0.002131084,0.0005082445],"domain_scores_gemma":[0.9978926,0.0003528249,0.0001272328,0.000643217,0.0006561578,0.0003279448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002931294,0.0004288988,0.08860677,0.002459614,0.0002364016,0.00001194645,0.004492899,0.00002823228,0.8172913,0.0002704746,0.0299694,0.05327276],"study_design_scores_gemma":[0.01110116,0.006784677,0.03559203,0.0002631282,0.0001822728,0.00005118114,0.001960644,0.003952218,0.9291993,0.0003646867,0.0102445,0.0003042364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908939,0.00190847,0.0003858175,0.001119902,0.0000380374,0.001399684,0.00002630647,0.00002242792,0.004205469],"genre_scores_gemma":[0.9986766,0.0003469292,0.000155836,0.00004951097,0.00004670668,0.0000552913,0.00003350931,0.00003959401,0.0005960456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.111908,"threshold_uncertainty_score":0.5292869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04372595349444621,"score_gpt":0.3564064783278312,"score_spread":0.312680524833385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}