{"id":"W2174638579","doi":"10.1093/brain/awv308","title":"MTHFSD and DDX58 are novel RNA-binding proteins abnormally regulated in amyotrophic lateral sclerosis","year":2015,"lang":"en","type":"article","venue":"Brain","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; Université Laval; Occupational Cancer Research Centre; University of Toronto","funders":"Canadian Institutes of Health Research; Fondation Brain Canada","keywords":"Amyotrophic lateral sclerosis; TARDBP; Biology; RNA-binding protein; Motor neuron; RNA; Stress granule; Gene; Cell biology; Pathology; Molecular biology; SOD1; Messenger RNA; Neuroscience; Genetics; Translation (biology); Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008089512,0.0002659027,0.0004685513,0.000388493,0.00008442633,0.00008737297,0.0001820119,0.0002109655,0.00008929637],"category_scores_gemma":[0.0005111079,0.000225059,0.00006765743,0.0006692338,0.0001721213,0.0002764507,0.00022284,0.0005335799,0.00008347017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003239054,"about_ca_system_score_gemma":0.0002226428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005768833,"about_ca_topic_score_gemma":0.0002079807,"domain_scores_codex":[0.9975449,0.0001160986,0.000436279,0.0005172772,0.0006775871,0.0007078914],"domain_scores_gemma":[0.9987183,0.00005997062,0.0001178926,0.0004023324,0.0001644697,0.000537076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001204088,0.0004740647,0.1303493,0.0001706334,0.0001000479,0.000387269,0.001454679,0.00006557317,0.8515373,0.0002706955,0.006700163,0.007286092],"study_design_scores_gemma":[0.007420903,0.0005092719,0.9836053,0.0009162033,0.00001695645,0.0001174994,0.0001099809,0.001709409,0.002370872,0.00009991832,0.002788845,0.0003348619],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978119,0.0001637919,0.00004182674,0.01980149,0.00007485977,0.0009550395,0.00001609602,0.0001084979,0.0007193726],"genre_scores_gemma":[0.9945071,0.00006072466,0.001490573,0.001416209,0.0001377316,0.00006291376,0.00002924526,0.00006141219,0.002234105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8532559,"threshold_uncertainty_score":0.9177642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08361607599688782,"score_gpt":0.2924962219899582,"score_spread":0.2088801459930704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}