{"id":"W2174753847","doi":"10.1093/brain/awv112","title":"Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation","year":2015,"lang":"en","type":"article","venue":"Brain","topic":"Medical Imaging Techniques and Applications","field":"Medicine","cited_by":433,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; Tau Consortium; Canadian Institutes of Health Research; Hellman Family Foundation","keywords":"Pittsburgh compound B; Positron emission tomography; Amyloid (mycology); Nuclear medicine; Positron emission; Dementia; Alzheimer's disease; Brain positron emission tomography; Neuroimaging; Psychology; Medicine; Pathology; Preclinical imaging; Neuroscience; In vivo; Disease; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01084184,0.0004938365,0.0006562653,0.001215325,0.0003382684,0.0009856856,0.0005777439,0.0007667182,0.0003675985],"category_scores_gemma":[0.03718103,0.0003630267,0.0004335007,0.0009060286,0.0009256392,0.0006304778,0.0006434221,0.0005401035,0.0002126883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003516283,"about_ca_system_score_gemma":0.0006083038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002335351,"about_ca_topic_score_gemma":0.003702837,"domain_scores_codex":[0.9974565,0.001177616,0.0003663391,0.0003272658,0.0005761705,0.00009608163],"domain_scores_gemma":[0.9823524,0.01184702,0.001757951,0.001694284,0.002040238,0.0003081124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00103205,0.00006824671,0.906882,0.0001956425,0.000378482,0.0007084779,0.0005974639,0.006244061,0.01277574,0.00123119,0.001129763,0.06875686],"study_design_scores_gemma":[0.00005630571,0.0007351109,0.9205207,0.00008108989,0.0003930981,0.003481788,0.0006621723,0.05350196,0.01214366,0.005442551,0.002901387,0.00008031266],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9342944,0.002864053,0.05972304,0.000308567,0.0000511622,0.0001400131,0.0003417535,0.0002767045,0.002000283],"genre_scores_gemma":[0.9890304,0.0001846955,0.01040446,0.00006195204,0.0000167178,0.00003055824,0.00012211,0.00002520975,0.0001237774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01084184,"threshold_uncertainty_score":0.05733782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1029160992891289,"score_gpt":0.3841546332085716,"score_spread":0.2812385339194426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}