{"id":"W2174778765","doi":"10.1089/109065701753617444","title":"A Primer for Predicting Risk of Disease in <i>HFE</i> -Linked Hemochromatosis","year":2001,"lang":"en","type":"article","venue":"Genetic Testing","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Hemochromatosis; Hereditary hemochromatosis; Penetrance; Proband; Genetics; Genotype; Allele; Genetic counseling; Population; Genetic testing; Compound heterozygosity; Heterozygote advantage; Medicine; Asymptomatic; Mutation; Biology; Internal medicine; Gene; Phenotype; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005561474,0.001312399,0.000879662,0.003332345,0.0009638824,0.001575046,0.001396631,0.003079643,0.01303682],"category_scores_gemma":[0.02552919,0.0008179052,0.0008539199,0.0009156443,0.0009727112,0.002494776,0.001254977,0.004108605,0.007682095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005303578,"about_ca_system_score_gemma":0.00138648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008502658,"about_ca_topic_score_gemma":0.001744941,"domain_scores_codex":[0.9968114,0.001941623,0.0004150446,0.0001892404,0.0005324005,0.0001103021],"domain_scores_gemma":[0.9849076,0.01002571,0.0007934709,0.0005205032,0.002679043,0.001073654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0006835181,0.0006772728,0.01989307,0.0009352369,0.0001609928,0.005784908,0.002407419,0.001537514,0.006949693,0.0183325,0.3928204,0.5498174],"study_design_scores_gemma":[0.000500725,0.001014751,0.0186167,0.004646829,0.0004012864,0.02366361,0.001947226,0.01217758,0.008196975,0.09105176,0.8374175,0.0003650198],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.02048671,0.02486853,0.6476743,0.1621744,0.03369873,0.003848642,0.005882301,0.01367184,0.08769455],"genre_scores_gemma":[0.05341714,0.009129035,0.8496706,0.04088936,0.00492432,0.003353273,0.002227502,0.0009794477,0.03540942],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.01303682,"threshold_uncertainty_score":0.04361248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02082149682298788,"score_gpt":0.2625133267360754,"score_spread":0.2416918299130875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}