{"id":"W2174938993","doi":"10.3324/haematol.2015.125864","title":"Impact of prior treatment and depth of response on survival in MM-003, a randomized phase 3 study comparing pomalidomide plus low-dose dexamethasone versus high-dose dexamethasone in relapsed/refractory multiple myeloma","year":2015,"lang":"en","type":"article","venue":"Haematologica","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Princess Margaret Cancer Centre; Vancouver General Hospital","funders":"Celgene","keywords":"Pomalidomide; Dexamethasone; Lenalidomide; Medicine; Internal medicine; Thalidomide; Refractory (planetary science); Multiple myeloma; Tolerability; Oncology; Gastroenterology; Adverse effect; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002002234,0.0007054722,0.001126478,0.0002547503,0.0002074249,0.000732613,0.0004432679,0.0007743856,0.001876124],"category_scores_gemma":[0.001552216,0.0002415709,0.001665543,0.0002613831,0.0004544794,0.0004623054,0.0003487723,0.001464918,0.0001875567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006318869,"about_ca_system_score_gemma":0.0007994137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006165445,"about_ca_topic_score_gemma":0.00144871,"domain_scores_codex":[0.9991702,0.0005568644,0.00004112503,0.00007997744,0.00005467157,0.00009725418],"domain_scores_gemma":[0.9986193,0.0004805334,0.0003199463,0.00006662307,0.00003052164,0.0004830663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9533349,0.006387237,0.00972329,0.0001457899,0.001005734,0.00003810476,0.00004821581,0.0006912911,0.005280694,0.00006556405,0.0003198852,0.02295934],"study_design_scores_gemma":[0.3972127,0.5051765,0.08486731,0.00008767979,0.002119559,0.0002310768,0.00007141312,0.003265577,0.004480125,0.0005473463,0.001885215,0.00005555722],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972857,0.001514828,0.0001548638,0.0001039148,0.00004027169,0.0002305082,0.0002380433,0.00001416467,0.0004176749],"genre_scores_gemma":[0.9981024,0.0003780474,0.0003309678,0.0002201834,0.0000657411,0.0002153654,0.0003493808,0.000006208552,0.0003317227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002002234,"threshold_uncertainty_score":0.010589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.121018489181188,"score_gpt":0.3982900003491797,"score_spread":0.2772715111679917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}