{"id":"W2175036106","doi":"10.1053/j.gastro.2015.10.026","title":"Targeting Integrins and Safety in an Emerging Class of Targeted Oral Therapies: Are We Prepared for Rational and Precision Choices?","year":2015,"lang":"en","type":"editorial","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; Robarts Clinical Trials; Western University","funders":"","keywords":"Natalizumab; Integrin; Ulcerative colitis; Medicine; Inflammatory bowel disease; Immunology; Cell adhesion molecule; Proinflammatory cytokine; Colitis; Pharmacology; Internal medicine; Disease; Multiple sclerosis; Inflammation; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01109995,0.002832994,0.004433422,0.001562114,0.001903864,0.006654725,0.003300097,0.02256528,0.004849628],"category_scores_gemma":[0.02503787,0.001115688,0.002129154,0.0009485973,0.00349221,0.006035307,0.001651396,0.03584677,0.004141114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003146284,"about_ca_system_score_gemma":0.003803686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001102469,"about_ca_topic_score_gemma":0.003788345,"domain_scores_codex":[0.9936827,0.001229763,0.0008827542,0.0005284533,0.00321119,0.0004650393],"domain_scores_gemma":[0.9789425,0.0117476,0.001591838,0.0004372766,0.005015278,0.002265494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000766422,0.00002593419,0.00002584728,0.0003451872,0.00003132724,0.0001418007,0.00001341223,0.00006521172,0.0001123148,0.001540903,0.9789834,0.01863809],"study_design_scores_gemma":[0.0001119379,0.00007456175,0.0001452944,0.0005682178,0.00007766642,0.0003346435,0.00002791598,0.0002409379,0.0001502409,0.003128044,0.9951088,0.00003169606],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.0000842033,0.05058592,0.0005226572,0.1217133,0.8246772,0.00002144547,0.0000494068,0.00008216664,0.002263674],"genre_scores_gemma":[0.0007411204,0.02737855,0.000427162,0.06115241,0.9034907,0.00002966987,0.00002503372,0.00002674704,0.00672868],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.02256528,"threshold_uncertainty_score":0.05870283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01200381617892294,"score_gpt":0.2834172116826154,"score_spread":0.2714133955036924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}