{"id":"W2175128471","doi":"10.1016/s0960-894x(03)00510-9","title":"Discovery of the first series of inhibitors of human papillomavirus type 11: inhibition of the assembly of the E1–E2–Origin DNA complex","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; DNA; Human papillomavirus; Series (stratigraphy); Structure–activity relationship; Stereochemistry; In vitro; Combinatorial chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003306674,0.0008582032,0.0007229308,0.0004678506,0.0003148928,0.0008011314,0.000652245,0.0006388339,0.002304288],"category_scores_gemma":[0.0004292598,0.0004042072,0.0004549766,0.0002483577,0.000287102,0.0003721159,0.0003919112,0.001380046,0.0006299687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007459312,"about_ca_system_score_gemma":0.0004607846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008275664,"about_ca_topic_score_gemma":0.003046273,"domain_scores_codex":[0.9998318,0.00002371251,0.00001197417,0.00002682984,0.00004338883,0.00006231156],"domain_scores_gemma":[0.99984,0.0000372108,0.00003165644,0.00001489421,0.00002673964,0.00004939094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001421217,0.001432753,0.001364002,0.0009976581,0.000319976,0.0008938013,0.000346396,0.003765762,0.8686768,0.004163027,0.0080593,0.1085593],"study_design_scores_gemma":[0.0008359188,0.004348245,0.002431708,0.00006565706,0.0001983827,0.001203573,0.00005012773,0.002723865,0.901282,0.0005537362,0.08624417,0.00006270552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8333691,0.09090733,0.03730284,0.002068692,0.0009792204,0.001843585,0.00302719,0.001117507,0.02938442],"genre_scores_gemma":[0.9180557,0.04114708,0.01805789,0.001153673,0.000192698,0.0004733659,0.002446009,0.0001143672,0.01835911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002304288,"threshold_uncertainty_score":0.007708609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03152733179759011,"score_gpt":0.2825992438841793,"score_spread":0.2510719120865892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}