{"id":"W2175151668","doi":"10.1530/erc-15-0386","title":"CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer","year":2015,"lang":"en","type":"article","venue":"Endocrine Related Cancer","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Medical Research Council; Canadian Institutes of Health Research; U.S. Public Health Service; Helse Vest; Hunter Medical Research Institute; National Health and Medical Research Council; Vincent Fairfax Family Foundation; Norges Forskningsråd; Kreftforeningen; Wellcome Trust; Cancer Research UK; Universitetet i Bergen; National Institute for Health and Care Research; Cancer Council Queensland; Haukeland Universitetssjukehus; Fred C. and Katherine B. Andersen Foundation; QIMR Berghofer Medical Research Institute; Francis Crick Institute; Mayo Foundation for Medical Education and Research; Cancer Council Tasmania; National Institutes of Health; Ovarian Cancer Research Fund; Breast Cancer Research Foundation","keywords":"Mendelian randomization; Endometrial cancer; Cancer; Randomization; Gynecology; Medicine; Oncology; Biology; Clinical trial; Internal medicine; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007263187,0.0005575386,0.001003288,0.0009721863,0.000591802,0.0007827481,0.0008879352,0.0006995388,0.005622675],"category_scores_gemma":[0.01882251,0.0003540949,0.001216352,0.001393928,0.000948375,0.0003729943,0.0006158471,0.0005169896,0.0004739594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002955761,"about_ca_system_score_gemma":0.000485953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002864655,"about_ca_topic_score_gemma":0.002248034,"domain_scores_codex":[0.9907737,0.006228145,0.0002634449,0.001857263,0.0005909551,0.0002863696],"domain_scores_gemma":[0.9883127,0.008434142,0.001137514,0.001694419,0.0001967557,0.0002245176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0113775,0.0002897519,0.7830203,0.000530527,0.008773692,0.007235025,0.0006392314,0.008992177,0.04122244,0.03109953,0.003945429,0.1028745],"study_design_scores_gemma":[0.003024312,0.001916267,0.8036669,0.0001946004,0.006153606,0.011787,0.0003401586,0.08934645,0.009949073,0.06251122,0.01095404,0.0001563096],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9052085,0.003023685,0.08382744,0.001002389,0.0001608477,0.0002324252,0.001402128,0.000465489,0.004677095],"genre_scores_gemma":[0.9889347,0.0003264946,0.009472501,0.0002182881,0.00005801738,0.0000938312,0.0002863204,0.00006022316,0.0005495878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007263187,"threshold_uncertainty_score":0.03841186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02217251667561125,"score_gpt":0.30153985889802,"score_spread":0.2793673422224087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}