{"id":"W2175151668","doi":"10.1530/erc-15-0386","title":"CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer","year":2015,"lang":"en","type":"article","venue":"Endocrine Related Cancer","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Medical Research Council; Canadian Institutes of Health Research; U.S. Public Health Service; Helse Vest; Hunter Medical Research Institute; National Health and Medical Research Council; Vincent Fairfax Family Foundation; Norges Forskningsråd; Kreftforeningen; Wellcome Trust; Cancer Research UK; Universitetet i Bergen; National Institute for Health and Care Research; Cancer Council Queensland; Haukeland Universitetssjukehus; Fred C. and Katherine B. Andersen Foundation; QIMR Berghofer Medical Research Institute; Francis Crick Institute; Mayo Foundation for Medical Education and Research; Cancer Council Tasmania; National Institutes of Health; Ovarian Cancer Research Fund; Breast Cancer Research Foundation","keywords":"Mendelian randomization; Endometrial cancer; Cancer; Randomization; Gynecology; Medicine; Oncology; Biology; Clinical trial; Internal medicine; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001874999,0.0002462406,0.0003046992,0.0001096115,0.0001040348,0.0000319035,0.000114298,0.000201321,0.00006063567],"category_scores_gemma":[0.0001639097,0.0002151169,0.0001225616,0.0002613014,0.0000715599,0.00001083939,0.00005913657,0.000182335,0.000005200043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000598035,"about_ca_system_score_gemma":0.00024582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001988027,"about_ca_topic_score_gemma":0.0000224357,"domain_scores_codex":[0.9986321,0.00006534749,0.000318774,0.0004448781,0.0001560671,0.0003828181],"domain_scores_gemma":[0.999245,0.00004118849,0.0001287834,0.0002045794,0.0001469494,0.0002334332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.009471112,0.0002848808,0.01306315,0.000299752,0.004785848,0.0001204038,0.001683215,0.00950144,0.6587273,0.0007560728,0.192487,0.1088198],"study_design_scores_gemma":[0.05749011,0.0009253306,0.0001454458,0.0001501163,0.0004580586,0.0002262568,0.0001334927,0.00423744,0.3781268,0.0003130616,0.5568234,0.0009705425],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9212668,0.06990813,0.001368137,0.002080665,0.001936528,0.001459785,0.0001841298,0.00007823174,0.00171762],"genre_scores_gemma":[0.9844015,0.007666559,0.000603454,0.0002677987,0.00122085,0.0005469494,0.0002211469,0.0000752,0.004996495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3643364,"threshold_uncertainty_score":0.8772211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02217251667561125,"score_gpt":0.30153985889802,"score_spread":0.2793673422224087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}