{"id":"W2175319049","doi":"10.1016/s0960-894x(02)00518-8","title":"Structure–Activity Relationship of Biaryl Acylsulfonamide Analogues on the Human EP3 Prostanoid Receptor","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Prostanoid; Chemistry; Receptor; Moiety; Chemical synthesis; Stereochemistry; Structure–activity relationship; Biochemistry; In vitro; Pharmacology; Combinatorial chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002251998,0.0002660641,0.0003164004,0.0001911504,0.0001449738,0.0001656002,0.0002357388,0.0002057387,0.002172794],"category_scores_gemma":[0.000231197,0.0001181344,0.0002369127,0.000213063,0.0001623157,0.0001780612,0.0001269134,0.0004030346,0.0003597325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002129824,"about_ca_system_score_gemma":0.0001727925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001189499,"about_ca_topic_score_gemma":0.002146391,"domain_scores_codex":[0.9999137,0.00002336254,0.000009497243,0.000008153459,0.00001552996,0.00002980029],"domain_scores_gemma":[0.9999026,0.00002787645,0.00002366367,0.0000081283,0.00001383761,0.00002384476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004430073,0.0003235443,0.0004648665,0.0000991015,0.00004699079,0.0002751497,0.00007370416,0.0008634807,0.9839166,0.0003037869,0.0003394453,0.008863152],"study_design_scores_gemma":[0.001401805,0.02847205,0.01047211,0.00002443911,0.0002810242,0.0009943902,0.0001153544,0.003937353,0.9464685,0.0001494094,0.007643944,0.00003959157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996102,0.002057128,0.0003063222,0.00007505745,0.00002770737,0.00002449611,0.0002172441,0.0000220488,0.001168129],"genre_scores_gemma":[0.9951295,0.002259044,0.000349548,0.00007044132,0.00002537704,0.00002560617,0.0005209,0.000005482807,0.001614059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002172794,"threshold_uncertainty_score":0.007268727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02516622063362908,"score_gpt":0.2361852915601961,"score_spread":0.211019070926567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}