{"id":"W2175362852","doi":"10.1093/glycob/cwv084","title":"Inhibition of Rab prenylation by statins induces cellular glycosphingolipid remodeling","year":2015,"lang":"en","type":"article","venue":"Glycobiology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Prenylation; Geranylgeranyl pyrophosphate; Rab; Geranylgeranylation; Golgi apparatus; Farnesyl pyrophosphate; Statin; Mevalonate pathway; Cholera toxin; Biochemistry; Glycosphingolipid; Chemistry; Geranylgeraniol; Biology; ATP synthase; Endoplasmic reticulum; Reductase; Pharmacology; Enzyme; GTPase; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002565049,0.0001288329,0.0001641072,0.00004194512,0.0000348025,0.000005810183,0.0000822518,0.000257923,0.00001616055],"category_scores_gemma":[0.00004648685,0.0001282215,0.00006262036,0.00007318905,0.00007634486,0.000006882655,0.00003104498,0.00008350875,0.000007336846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001703444,"about_ca_system_score_gemma":0.00006652354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009321867,"about_ca_topic_score_gemma":0.0000314183,"domain_scores_codex":[0.9990702,0.00007170267,0.0003006454,0.0002799649,0.00009195206,0.0001855783],"domain_scores_gemma":[0.9994357,0.000006991922,0.0001457322,0.0001992534,0.0001378098,0.0000745728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001715139,0.00004301691,0.00109838,0.00001342257,0.00001686757,8.327261e-7,0.0002088532,0.0001839146,0.9970922,0.00006690605,0.0003703084,0.0007338199],"study_design_scores_gemma":[0.0009143484,0.0004787423,0.0001564501,0.0000116406,0.00002083649,0.00000607559,0.0001426684,0.0003714161,0.9733135,0.0003711061,0.0240359,0.0001773061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9414845,0.0009814856,0.05655048,0.00004578583,0.0002380839,0.0001376698,0.00004676963,0.00001580029,0.0004994131],"genre_scores_gemma":[0.9878695,0.0001089651,0.00059245,0.00005944473,0.0001808456,0.000008039963,0.01105992,0.00001565712,0.0001051781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05595803,"threshold_uncertainty_score":0.522872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01682225402485655,"score_gpt":0.2299871061240418,"score_spread":0.2131648520991852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}