{"id":"W2175362852","doi":"10.1093/glycob/cwv084","title":"Inhibition of Rab prenylation by statins induces cellular glycosphingolipid remodeling","year":2015,"lang":"en","type":"article","venue":"Glycobiology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Prenylation; Geranylgeranyl pyrophosphate; Rab; Geranylgeranylation; Golgi apparatus; Farnesyl pyrophosphate; Statin; Mevalonate pathway; Cholera toxin; Biochemistry; Glycosphingolipid; Chemistry; Geranylgeraniol; Biology; ATP synthase; Endoplasmic reticulum; Reductase; Pharmacology; Enzyme; GTPase; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002694879,0.0003922431,0.0005635298,0.0002105349,0.0001806477,0.0003736884,0.0001718581,0.0002966009,0.001331056],"category_scores_gemma":[0.000183053,0.0001916185,0.0004366398,0.0002259306,0.0002698149,0.0002660904,0.0003057675,0.0008230673,0.0005891695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003293573,"about_ca_system_score_gemma":0.0003966175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001040432,"about_ca_topic_score_gemma":0.00125146,"domain_scores_codex":[0.9996958,0.00006111027,0.00004263598,0.00004431243,0.00005281255,0.0001033859],"domain_scores_gemma":[0.9998592,0.00002553082,0.00002607246,0.00003032386,0.00002265251,0.00003621104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003741711,0.00004476138,0.0001059918,0.00003866663,0.000008628019,0.00003879161,0.00001507287,0.00002954921,0.9980538,0.00007697399,0.00005179192,0.001161767],"study_design_scores_gemma":[0.00003320966,0.0004339969,0.00208936,0.00000527142,0.00001847929,0.00008521584,0.00002763297,0.0005406799,0.994817,0.00004087227,0.001904462,0.000003835161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897446,0.002912121,0.00324747,0.0003276144,0.0001084704,0.00007887198,0.0007131259,0.0002034373,0.002664323],"genre_scores_gemma":[0.9922671,0.001794333,0.001758282,0.0001481795,0.00002074868,0.00008644575,0.0009305635,0.00003453983,0.002959882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001331056,"threshold_uncertainty_score":0.004452825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01682225402485655,"score_gpt":0.2299871061240418,"score_spread":0.2131648520991852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}