{"id":"W2175428656","doi":"10.1016/j.chembiol.2015.09.018","title":"Optogenetic Inhibitor of the Transcription Factor CREB","year":2015,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of Mental Health; Canada Foundation for Innovation; National Institutes of Health; National Science Foundation","keywords":"CREB; Optogenetics; Transcription factor; Transcription (linguistics); Activating transcription factor; Biology; Cell biology; Endogeny; Genetics; Neuroscience; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001039309,0.0002872838,0.0002156079,0.0002324086,0.000197318,0.0003272762,0.0005697623,0.0002888977,0.004139048],"category_scores_gemma":[0.0001776533,0.0001338627,0.0002725025,0.0001469441,0.0003730406,0.0002289452,0.000250697,0.000912655,0.000434852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000636431,"about_ca_system_score_gemma":0.0006037364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002129639,"about_ca_topic_score_gemma":0.002879664,"domain_scores_codex":[0.99989,0.000004723791,0.000002891862,0.00001928572,0.00002825897,0.00005485804],"domain_scores_gemma":[0.9999176,0.0000224111,0.00001426694,0.00001188535,0.000006447556,0.00002730446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005028507,0.00007897251,0.00006695493,0.00004607322,0.000007740647,0.00005814133,0.00001059765,0.0002194089,0.9933536,0.001896656,0.0003734722,0.003385598],"study_design_scores_gemma":[0.00006326626,0.0001350307,0.0007795435,0.000006792183,0.00001506728,0.00006922115,0.00002710957,0.001627177,0.9937836,0.0004139988,0.003073691,0.000005503904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9615588,0.002202026,0.01210119,0.00137271,0.0006098638,0.00008402234,0.0008675347,0.0004414101,0.02076242],"genre_scores_gemma":[0.9881051,0.0009444595,0.002309212,0.0001466529,0.00003650891,0.00003254973,0.0002031611,0.00006327032,0.008159108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004139048,"threshold_uncertainty_score":0.01384646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1034618956937833,"score_gpt":0.3295933584149766,"score_spread":0.2261314627211932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}