{"id":"W2175428656","doi":"10.1016/j.chembiol.2015.09.018","title":"Optogenetic Inhibitor of the Transcription Factor CREB","year":2015,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of Mental Health; Canada Foundation for Innovation; National Institutes of Health; National Science Foundation","keywords":"CREB; Optogenetics; Transcription factor; Transcription (linguistics); Activating transcription factor; Biology; Cell biology; Endogeny; Genetics; Neuroscience; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007539502,0.00009370861,0.0001160718,0.0000132162,0.00004193881,0.000008597642,0.0004353363,0.0001255794,0.0002078483],"category_scores_gemma":[0.0003732471,0.00006433934,0.00007117174,0.0001547942,0.0003682035,0.00001670582,0.00008685332,0.0001405903,0.00001948714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003555793,"about_ca_system_score_gemma":0.0001122556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007703105,"about_ca_topic_score_gemma":7.650346e-7,"domain_scores_codex":[0.9991374,0.00007745917,0.0001587085,0.0002477273,0.0001550184,0.0002236681],"domain_scores_gemma":[0.999443,0.00004836411,0.0000513828,0.0002904719,0.00005745311,0.0001093569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002696353,0.00003347473,0.002054177,0.00001489042,0.000001778996,3.277095e-7,0.0001074863,0.000002862693,0.9970778,0.00001532648,0.0001581862,0.0005067896],"study_design_scores_gemma":[0.0002732445,0.00004227366,0.0005012245,0.00000493084,0.00000265716,0.000006806818,0.00002348761,0.00004464173,0.9897942,0.0002171715,0.009020119,0.00006923761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954236,0.0001439653,0.00002543905,0.0001182336,0.0002907071,0.0001064533,0.00006317392,0.00001586527,0.003812583],"genre_scores_gemma":[0.9991949,0.00003542019,0.00002466597,0.00006309227,0.0001150344,0.00001053653,0.000003770905,0.000008459763,0.0005441466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008861932,"threshold_uncertainty_score":0.2623682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1034618956937833,"score_gpt":0.3295933584149766,"score_spread":0.2261314627211932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}