{"id":"W2175799135","doi":"10.1016/j.bmcl.2015.10.015","title":"A selective inhibitor of the UFM1-activating enzyme, UBA5","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; National Institutes of Health","keywords":"Chemistry; Enzyme; Enzyme inhibitor; Stereochemistry; Biochemistry; Structure–activity relationship; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002101496,0.0004900101,0.0004378842,0.0003050641,0.0002831973,0.000328402,0.0005692707,0.0004193592,0.001972609],"category_scores_gemma":[0.0001306703,0.0001572549,0.0003108007,0.0002541983,0.0001704702,0.0002607265,0.000186906,0.0006056124,0.0005244716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007200183,"about_ca_system_score_gemma":0.0004099872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008143204,"about_ca_topic_score_gemma":0.001764629,"domain_scores_codex":[0.9998741,0.00001245676,0.00001038477,0.00002927585,0.00002803241,0.0000457075],"domain_scores_gemma":[0.9999585,0.000007514435,0.000007913728,0.000005227882,0.00000544382,0.00001533924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009251669,0.0002067429,0.0002852675,0.0003062569,0.00008182868,0.0002587927,0.00002806602,0.0004384289,0.9712469,0.001756368,0.001904641,0.02256143],"study_design_scores_gemma":[0.0001325029,0.0006192537,0.0009366365,0.00001253192,0.00005692648,0.0006118836,0.00001691409,0.001470766,0.9836671,0.0001222781,0.01234177,0.00001144007],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9258156,0.03629481,0.01366494,0.001047839,0.0006823499,0.0002338201,0.0017778,0.0009966905,0.01948605],"genre_scores_gemma":[0.9848483,0.005476302,0.004005606,0.0002352411,0.00003839326,0.0000581159,0.00106119,0.00001802006,0.004258847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001972609,"threshold_uncertainty_score":0.006599069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01654766238647372,"score_gpt":0.2288560653593564,"score_spread":0.2123084029728827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}