{"id":"W2175853567","doi":"10.1038/nature09380","title":"Mediator and cohesin connect gene expression and chromatin architecture","year":2010,"lang":"en","type":"article","venue":"Nature","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1942,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Human Genome Research Institute; Canadian Institutes of Health Research","keywords":"Cohesin; Enhancer; Promoter; Biology; Chromatin; Cell biology; Transcription factor; Homeobox protein NANOG; Molecular biology; Genetics; Induced pluripotent stem cell; Gene; Embryonic stem cell; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002733946,0.0001990867,0.0002344463,0.000404688,0.0003407024,0.001104935,0.0005251056,0.0006114038,0.001761991],"category_scores_gemma":[0.0008715703,0.0005177591,0.0001534444,0.0003861838,0.0007217719,0.0015559,0.0007004067,0.0006996118,0.0006214885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004312788,"about_ca_system_score_gemma":0.0002785356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006042445,"about_ca_topic_score_gemma":0.00104321,"domain_scores_codex":[0.9998279,0.00002638264,0.000006133326,0.00004820854,0.00005871919,0.0000326275],"domain_scores_gemma":[0.9996352,0.0001398419,0.00005635692,0.00007060407,0.00004177914,0.00005614475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002078327,0.00002908567,0.003416284,0.00006680762,0.00002112972,0.0001639398,0.0001417922,0.001437086,0.9445083,0.03212103,0.0005420898,0.01734466],"study_design_scores_gemma":[0.00008331504,0.0002077507,0.1114609,0.00004158586,0.00007490524,0.001011292,0.000428566,0.02129198,0.770315,0.06953879,0.02547391,0.00007191444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8716565,0.009738423,0.09739657,0.00222707,0.0003691582,0.00004978085,0.0005316327,0.000671864,0.01735896],"genre_scores_gemma":[0.9876462,0.001593802,0.005608048,0.0002078112,0.00009035584,0.00001777533,0.0002302016,0.00006080209,0.004545245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001761991,"threshold_uncertainty_score":0.005894482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.001682781224349077,"score_gpt":0.2024064799523168,"score_spread":0.2007236987279677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}