{"id":"W2175975424","doi":"10.1093/jac/dkv380","title":"Phase 3 pharmacokinetics and safety study of a posaconazole tablet formulation in patients at risk for invasive fungal disease","year":2015,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":169,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Juravinski Hospital","funders":"National Cancer Institute; National Institutes of Health","keywords":"Posaconazole; Pharmacokinetics; Medicine; Pharmacology; Antifungal; Dermatology; Amphotericin B","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001265137,0.001097992,0.001762972,0.0002772697,0.0003603591,0.001006638,0.0006121119,0.00105722,0.004518898],"category_scores_gemma":[0.001197585,0.0005347601,0.001191948,0.0003845034,0.0006042079,0.0006631435,0.000314584,0.003146546,0.0009958128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008784751,"about_ca_system_score_gemma":0.001952464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001077622,"about_ca_topic_score_gemma":0.001652474,"domain_scores_codex":[0.9995162,0.0002179761,0.00001961373,0.0000880787,0.00007193699,0.00008607136],"domain_scores_gemma":[0.9992303,0.0001183746,0.0001963328,0.0000859893,0.00008574184,0.000283357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.717186,0.09137035,0.01029833,0.0008864653,0.001495012,0.0004695051,0.0004656444,0.003035573,0.07387792,0.0003142163,0.006688198,0.09391288],"study_design_scores_gemma":[0.4278159,0.5398518,0.02061855,0.00004404163,0.0003618605,0.0005623073,0.00006504692,0.0025155,0.004588085,0.0002091357,0.003325708,0.00004190607],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992455,0.001130629,0.0008900682,0.0003545092,0.00006482288,0.002650493,0.001360446,0.000099327,0.000994719],"genre_scores_gemma":[0.9896222,0.0009585578,0.00185148,0.0009813053,0.00008879218,0.002624098,0.002195305,0.00003990187,0.001638322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004518898,"threshold_uncertainty_score":0.01511723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02026314840188952,"score_gpt":0.3088291222517037,"score_spread":0.2885659738498142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}