{"id":"W2176025995","doi":"10.1016/j.bmcl.2004.07.001","title":"Synthesis of a novel tetrahydroisoquinolino[2,1-c][1,4]benzodiazepine ring system with DNA recognition potential","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and pharmacology of benzodiazepine derivatives","field":"Chemistry","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Benzodiazepine; Ring (chemistry); Stereochemistry; DNA; Combinatorial chemistry; Biochemistry; Organic chemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002307257,0.0004727292,0.0006746323,0.00008388636,0.0001482824,0.00002228193,0.0004610856,0.0002490918,0.0009868554],"category_scores_gemma":[0.0001659219,0.0004252685,0.0001742363,0.0002812152,0.000444732,0.0001318276,0.00006732404,0.000407227,0.00002049209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002955631,"about_ca_system_score_gemma":0.0001555038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001119395,"about_ca_topic_score_gemma":0.000002188806,"domain_scores_codex":[0.9975082,0.0000205032,0.0006755796,0.0006428894,0.0005919358,0.0005608375],"domain_scores_gemma":[0.9985245,0.0001622482,0.0005030506,0.0004424841,0.0001184938,0.0002491859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002073278,0.0002642043,0.0001533206,0.001377676,0.0003234114,0.0001324609,0.0001933635,0.00008710913,0.9961252,0.000005322593,0.00007084118,0.001059746],"study_design_scores_gemma":[0.0026246,0.00002987586,0.0004464299,0.001618236,0.0003728472,0.000621028,0.001075414,0.0001104117,0.9925647,0.000003205251,0.0000623712,0.000470859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935197,0.0002127808,0.001837479,0.001762535,0.0001159214,0.0001164551,0.0001357869,0.0002107682,0.002088571],"genre_scores_gemma":[0.997408,0.00003001869,0.001312902,0.0002326786,0.0008002685,0.0000521772,0.00007267132,0.00007479899,0.00001646907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003888312,"threshold_uncertainty_score":0.9999264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01480210969593227,"score_gpt":0.2169001853397071,"score_spread":0.2020980756437749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}