{"id":"W2176093842","doi":"10.18632/oncotarget.6113","title":"Concepts and mechanisms underlying chemotherapy induced immunogenic cell death: impact on clinical studies and considerations for combined therapies","year":2015,"lang":"en","type":"review","venue":"Oncotarget","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Beatrice Hunter Cancer Research Institute; Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Immunogenic cell death; Medicine; Chemotherapy; Immunotherapy; Cancer research; Immunology; Calreticulin; Programmed cell death; Chemokine; CXCL10; Immune system; Cancer; Apoptosis; Biology; Internal medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007478397,0.0005216363,0.001820964,0.0001455226,0.0003661358,0.00005954803,0.00009249002,0.000670735,0.0002224139],"category_scores_gemma":[0.0001884036,0.0003663073,0.0004254213,0.00006161694,0.0001663426,0.0001006138,0.00005534885,0.0006054954,0.0000868389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001455712,"about_ca_system_score_gemma":0.0002762797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001662748,"about_ca_topic_score_gemma":0.000002586024,"domain_scores_codex":[0.9977828,0.000591483,0.0007828905,0.0004966874,0.00004120714,0.0003049246],"domain_scores_gemma":[0.9971892,0.001775366,0.0005019425,0.0002957288,0.0001954561,0.00004235429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003873596,0.001979506,0.0001440539,0.008245858,0.02946427,0.00001681106,0.00656804,0.000001575223,0.02783769,0.01707807,0.1985619,0.7062287],"study_design_scores_gemma":[0.004958197,0.005158734,0.00007151713,0.001442278,0.0008982406,0.0001105076,0.0008928434,0.000002849952,0.0003071987,0.004826224,0.9806674,0.0006640136],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003499434,0.991712,0.00009147394,0.0001087233,0.003013367,0.001286597,0.00003543315,0.00006735146,0.0001856507],"genre_scores_gemma":[0.007166292,0.9888764,0.0003168,0.0004125143,0.00004677527,0.0001632402,0.0002615732,0.00006364892,0.002692778],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7821056,"threshold_uncertainty_score":0.9998789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2566012546173865,"score_gpt":0.4660982824344628,"score_spread":0.2094970278170762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}