{"id":"W2176093842","doi":"10.18632/oncotarget.6113","title":"Concepts and mechanisms underlying chemotherapy induced immunogenic cell death: impact on clinical studies and considerations for combined therapies","year":2015,"lang":"en","type":"review","venue":"Oncotarget","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Beatrice Hunter Cancer Research Institute; Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Immunogenic cell death; Medicine; Chemotherapy; Immunotherapy; Cancer research; Immunology; Calreticulin; Programmed cell death; Chemokine; CXCL10; Immune system; Cancer; Apoptosis; Biology; Internal medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01036984,0.001494316,0.003757696,0.002328829,0.0006156531,0.004379739,0.002514882,0.004738874,0.005239406],"category_scores_gemma":[0.004954813,0.0004018067,0.001631738,0.001386199,0.002979562,0.00661289,0.002218823,0.006842857,0.00215997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002416056,"about_ca_system_score_gemma":0.00357717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006428249,"about_ca_topic_score_gemma":0.001624607,"domain_scores_codex":[0.9980878,0.0008575182,0.0003144259,0.0002108378,0.0003843293,0.0001449773],"domain_scores_gemma":[0.9930078,0.004383112,0.0006298647,0.0002741907,0.001263673,0.000441395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001096679,0.0004930513,0.001168931,0.01768974,0.0002393702,0.001943701,0.0003308588,0.001124379,0.004947579,0.03593825,0.03886867,0.8961588],"study_design_scores_gemma":[0.00040375,0.002882409,0.002768771,0.021501,0.0005961129,0.006450941,0.0008721933,0.001230279,0.002012608,0.05769536,0.9033514,0.000235222],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003595794,0.9869198,0.001134759,0.009048023,0.0008151045,0.00002991397,0.00002351614,0.00001764778,0.001651687],"genre_scores_gemma":[0.004604889,0.9820139,0.002801942,0.005876325,0.003613278,0.0001228899,0.00006568558,0.00001443035,0.0008867166],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01036984,"threshold_uncertainty_score":0.0548417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2566012546173865,"score_gpt":0.4660982824344628,"score_spread":0.2094970278170762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}