{"id":"W2176134948","doi":"10.1074/mcp.m115.050724","title":"The Human Tau Interactome: Binding to the Ribonucleoproteome, and Impaired Binding of the Proline-to-Leucine Mutant at Position 301 (P301L) to Chaperones and the Proteasome","year":2015,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Occupational Cancer Research Centre","funders":"Canadian Institutes of Health Research","keywords":"Interactome; Proteostasis; Proteome; Cell biology; Biology; Proteasome; Progressive supranuclear palsy; Chaperone (clinical); Mutant; Frontotemporal dementia; Ribonucleoprotein; Biochemistry; Chemistry; RNA; Genetics; Dementia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001157421,0.000396682,0.0002463604,0.000232993,0.0001944236,0.0002092872,0.0001113674,0.0002821979,0.0005201386],"category_scores_gemma":[0.0001054847,0.0001353373,0.0002112089,0.0001370331,0.0001607594,0.0001068935,0.0001256284,0.000261947,0.0002890007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002972018,"about_ca_system_score_gemma":0.0001454382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007822914,"about_ca_topic_score_gemma":0.001337413,"domain_scores_codex":[0.999876,0.00001616831,0.00001001637,0.0000345015,0.00004384185,0.00001941534],"domain_scores_gemma":[0.9999235,0.00001269682,0.0000261362,0.000008914896,0.000008440156,0.00002034954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007959087,0.00001231238,0.0001921372,0.00001455597,0.000004804111,0.000113214,0.00000939743,0.00002827801,0.9992411,0.00001471567,0.00002160775,0.0002684428],"study_design_scores_gemma":[0.00001412081,0.0003286852,0.03534295,0.000006834947,0.00003791007,0.001969242,0.00003591863,0.001761837,0.9591274,0.00009997504,0.001267133,0.000007911811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970824,0.0008362694,0.001139475,0.00007271596,0.00001334548,0.00001744461,0.0003670379,0.00003644795,0.0004347644],"genre_scores_gemma":[0.9949318,0.0004665735,0.001535633,0.00007288382,0.00001611475,0.00003645983,0.001102263,0.00001687934,0.001821362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007822914,"threshold_uncertainty_score":0.002156377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01727471138551399,"score_gpt":0.2759676317316715,"score_spread":0.2586929203461575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}