{"id":"W2176134948","doi":"10.1074/mcp.m115.050724","title":"The Human Tau Interactome: Binding to the Ribonucleoproteome, and Impaired Binding of the Proline-to-Leucine Mutant at Position 301 (P301L) to Chaperones and the Proteasome","year":2015,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Occupational Cancer Research Centre","funders":"Canadian Institutes of Health Research","keywords":"Interactome; Proteostasis; Proteome; Cell biology; Biology; Proteasome; Progressive supranuclear palsy; Chaperone (clinical); Mutant; Frontotemporal dementia; Ribonucleoprotein; Biochemistry; Chemistry; RNA; Genetics; Dementia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001251142,0.0003323842,0.0003940726,0.0001463862,0.0008085195,0.0001531072,0.0004014648,0.00008617081,0.000006206959],"category_scores_gemma":[0.0003996078,0.0001491909,0.0001453161,0.0005450093,0.0003134634,0.00007621581,0.0008239138,0.0003185339,0.00003403416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002333065,"about_ca_system_score_gemma":0.0001461132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001361163,"about_ca_topic_score_gemma":0.00003345183,"domain_scores_codex":[0.9973924,0.0003610891,0.0004291229,0.0004799563,0.0007664326,0.0005709684],"domain_scores_gemma":[0.9980915,0.00006395258,0.0001823988,0.000870042,0.0002328308,0.0005593103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00242796,0.0001850987,0.003826026,0.00009612273,0.001209564,0.0001138395,0.00289653,0.0000354973,0.9878745,0.0003851418,0.00009649493,0.0008532298],"study_design_scores_gemma":[0.004849,0.001192118,0.004895085,0.0004058318,0.000483058,0.0001704074,0.0006520902,0.0006914363,0.9855615,0.0003166761,0.0005062904,0.000276521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9726926,0.001190602,0.000254167,0.01392893,0.00006958861,0.01173275,0.0000447546,0.00003088054,0.00005572903],"genre_scores_gemma":[0.9974949,0.0000251804,0.0005150808,0.0004230597,0.00009211213,0.001215112,0.00002667859,0.00006465767,0.0001432112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02480231,"threshold_uncertainty_score":0.621856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01727471138551399,"score_gpt":0.2759676317316715,"score_spread":0.2586929203461575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}