{"id":"W2176159296","doi":"10.1007/978-1-60761-287-2_2","title":"Life at the Interface Between a Dynamic Environment and a Fixed Genome: Epigenetic Programming of Stress Responses by Maternal Behavior","year":2009,"lang":"en","type":"book-chapter","venue":"Humana Press eBooks","topic":"Neuroendocrine regulation and behavior","field":"Psychology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Discovery Centre; Hospital for Sick Children","funders":"","keywords":"Epigenetics; Offspring; Biology; Epigenome; Phenotype; DNA methylation; Hippocampal formation; Corticosterone; Histone; Neuroscience; Genetics; Psychology; Gene expression; Endocrinology; Gene; Hormone; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001279274,0.000146841,0.0001903801,0.0001330737,0.0002600746,0.0005314483,0.0001863652,0.0003288864,0.001197556],"category_scores_gemma":[0.00009656309,0.00007568597,0.0001720117,0.0001774886,0.0005523236,0.0004430998,0.0002972709,0.0004806884,0.0001863098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003350057,"about_ca_system_score_gemma":0.0002911296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006451535,"about_ca_topic_score_gemma":0.00198117,"domain_scores_codex":[0.9999411,0.00001094748,0.000002557267,0.0000208987,0.00001237649,0.00001217002],"domain_scores_gemma":[0.999959,0.000009436263,0.00001040948,0.000003294652,0.000007648272,0.00001032334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002367229,0.00005719311,0.01298874,0.0008206,0.000113903,0.002179749,0.003352151,0.0004264696,0.8107986,0.03937365,0.002077844,0.1275745],"study_design_scores_gemma":[0.00002579865,0.001245829,0.3871778,0.0007454577,0.0003608112,0.006657245,0.006576461,0.001810382,0.2846732,0.04914387,0.2614391,0.0001442043],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7169764,0.1913881,0.04992931,0.01189493,0.0008975688,0.00004473969,0.0005722438,0.0002034666,0.02809318],"genre_scores_gemma":[0.8993778,0.07360799,0.01135017,0.00163786,0.0002740009,0.00003367591,0.0001954161,0.00003710432,0.01348598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001197556,"threshold_uncertainty_score":0.004006207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05178435066245904,"score_gpt":0.323631929957457,"score_spread":0.2718475792949979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}