{"id":"W2176166968","doi":"10.1038/ncomms9715","title":"Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":774,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Hospital and Health Sciences Centre; University of British Columbia","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; Japan Society for the Promotion of Science; American Heart Association; University of Washington; Canadian Institutes of Health Research; National Institutes of Health; University of British Columbia; Harvard Stem Cell Institute; Massachusetts General Hospital; Seattle Children's Research Institute; Brigham and Women's Hospital; Heart and Stroke Foundation of Canada","keywords":"Induced pluripotent stem cell; Cell biology; Biology; Cilium; Epiblast; Organoid; Kidney; Polycystic kidney disease; Regeneration (biology); Regenerative medicine; CRISPR; Pathology; Stem cell; Genetics; Embryonic stem cell; Medicine; Gastrulation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008602096,0.0002001449,0.0001484085,0.00003525189,0.0002772926,0.00004214987,0.0008317604,0.0003268243,0.00001773919],"category_scores_gemma":[0.0001039866,0.0001578079,0.00007977534,0.0001729734,0.0002022013,0.000009006377,0.000301847,0.0006293078,0.00001551817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005601009,"about_ca_system_score_gemma":0.0005473416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001485109,"about_ca_topic_score_gemma":0.00009613842,"domain_scores_codex":[0.9989541,0.0001039002,0.0002061843,0.000320486,0.0001988943,0.000216472],"domain_scores_gemma":[0.9972726,0.00001101787,0.000102282,0.001610041,0.0002598034,0.0007442597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007078831,0.0006351418,0.005195585,0.00003761716,0.0008851894,0.00002412578,0.0007083652,0.02729739,0.8860887,0.001633061,0.07633083,0.0004560784],"study_design_scores_gemma":[0.005490538,0.0005857437,0.00120996,0.0005034351,0.0006560003,0.00002542287,0.0007046356,0.02077623,0.2203371,0.001819674,0.7462841,0.00160721],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9168579,0.03162418,0.02214209,0.01938728,0.0005655001,0.0008244856,0.0008131101,0.0001755007,0.007609942],"genre_scores_gemma":[0.9886141,0.001272078,0.005327664,0.00193539,0.0001548586,0.00003661094,0.002278787,0.00003964645,0.0003408813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6699532,"threshold_uncertainty_score":0.643522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01712817325773073,"score_gpt":0.2649808971038922,"score_spread":0.2478527238461615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}