{"id":"W2176166968","doi":"10.1038/ncomms9715","title":"Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":774,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Hospital and Health Sciences Centre; University of British Columbia","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; Japan Society for the Promotion of Science; American Heart Association; University of Washington; Canadian Institutes of Health Research; National Institutes of Health; University of British Columbia; Harvard Stem Cell Institute; Massachusetts General Hospital; Seattle Children's Research Institute; Brigham and Women's Hospital; Heart and Stroke Foundation of Canada","keywords":"Induced pluripotent stem cell; Cell biology; Biology; Cilium; Epiblast; Organoid; Kidney; Polycystic kidney disease; Regeneration (biology); Regenerative medicine; CRISPR; Pathology; Stem cell; Genetics; Embryonic stem cell; Medicine; Gastrulation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003517206,0.0003437126,0.0003451059,0.0003529268,0.0002452614,0.000570079,0.0004274299,0.0005030787,0.001146316],"category_scores_gemma":[0.0001914083,0.0003212301,0.0004818279,0.0001793531,0.0003506831,0.0002951017,0.0004805947,0.0009958455,0.0003996438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004296733,"about_ca_system_score_gemma":0.0005062806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001555416,"about_ca_topic_score_gemma":0.002069504,"domain_scores_codex":[0.9996935,0.00004140507,0.00004670968,0.0000592649,0.0001231842,0.00003585231],"domain_scores_gemma":[0.9997523,0.00005947869,0.00005137682,0.00006767461,0.00002400776,0.00004518819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004718711,0.00001948863,0.0002912643,0.00005580916,0.00001453761,0.000167015,0.00007312289,0.002011121,0.9950559,0.0006583835,0.0001254517,0.001480618],"study_design_scores_gemma":[0.00001372062,0.00007618252,0.001065682,0.00001012123,0.00001932568,0.0003070762,0.00003246395,0.007333608,0.9861206,0.000135135,0.004874421,0.00001160022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8545821,0.001143057,0.1335819,0.0002588958,0.000208958,0.0003134229,0.002458559,0.001439218,0.006013831],"genre_scores_gemma":[0.9412952,0.0008022516,0.05156035,0.00006677493,0.00001057347,0.0002133758,0.001345419,0.0002043806,0.0045017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001555416,"threshold_uncertainty_score":0.003834784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01712817325773073,"score_gpt":0.2649808971038922,"score_spread":0.2478527238461615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}