{"id":"W2176206542","doi":"10.1371/journal.pone.0139058","title":"The H29D Mutation Does Not Enhance Cytosolic Ca2+ Activation of the Cardiac Ryanodine Receptor","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates - Health Solutions; Heart and Stroke Foundation of Canada","keywords":"Ryanodine receptor 2; Ryanodine receptor; Mutation; Mutant; Cytosol; HEK 293 cells; Cell biology; Biology; Chemistry; Biophysics; Genetics; Biochemistry; Receptor; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002082704,0.0003971658,0.0004689665,0.0001549453,0.0001956105,0.0002732497,0.0003823756,0.0007162778,0.001857701],"category_scores_gemma":[0.0003260796,0.0001710409,0.0004749389,0.0001287698,0.0004001437,0.0002408545,0.000365194,0.0006761734,0.0007390956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001839276,"about_ca_system_score_gemma":0.0002051537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006856047,"about_ca_topic_score_gemma":0.0005013831,"domain_scores_codex":[0.9996436,0.00006942842,0.00006960092,0.00006331364,0.0001149022,0.00003924842],"domain_scores_gemma":[0.9995887,0.0001178383,0.00008073528,0.00007210099,0.00003348224,0.0001071753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000939842,0.00005264966,0.0001417718,0.00002107143,0.00001365132,0.0003449854,0.000009632106,0.00008241085,0.9985971,0.0001023651,0.00004256139,0.0004977737],"study_design_scores_gemma":[0.00009919365,0.0006848276,0.005430592,0.00001090602,0.0000410565,0.002498685,0.00004980018,0.003172928,0.984575,0.0001020443,0.003312483,0.00002236597],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948602,0.000391145,0.002290368,0.0001698839,0.00008773967,0.0000481602,0.0006196346,0.00006334991,0.001469446],"genre_scores_gemma":[0.9965107,0.0002144727,0.001250156,0.0001116066,0.0000232362,0.00002596178,0.0004958503,0.00004828295,0.00131962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001857701,"threshold_uncertainty_score":0.006214619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0246902977922744,"score_gpt":0.2484976851468743,"score_spread":0.2238073873545999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}