{"id":"W2176244692","doi":"10.1016/j.bmcl.2004.01.076","title":"Sulfonamido, azidosulfonyl and N-acetylsulfonamido analogues of rofecoxib: 4-[4-(N-acetylsulfonamido)phenyl]-3-(4-methanesulfonylphenyl)-2(5H)furanone is a potent and selective cyclooxygenase-2 inhibitor","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Rofecoxib; Chemistry; Cyclooxygenase; Enzyme inhibitor; Prostaglandin-Endoperoxide Synthase; Stereochemistry; Pharmacology; In vitro; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001982199,0.0002571856,0.0003089336,0.0002044537,0.000146228,0.0001695171,0.0003192715,0.0002240655,0.001394627],"category_scores_gemma":[0.0001611006,0.000107506,0.0001689125,0.0001388434,0.0002413053,0.000176539,0.0001171329,0.0003514276,0.000365982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002104185,"about_ca_system_score_gemma":0.0002803317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007271982,"about_ca_topic_score_gemma":0.001475869,"domain_scores_codex":[0.9998815,0.00002487392,0.00001280087,0.00001260225,0.00003252433,0.00003574716],"domain_scores_gemma":[0.9999181,0.000009877403,0.00002342564,0.000008993941,0.000008804049,0.00003073073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001413381,0.0001620497,0.0004444395,0.00008317774,0.00002387008,0.0003056058,0.0000421511,0.0004654491,0.9822714,0.0008216922,0.0005461282,0.0134207],"study_design_scores_gemma":[0.0007822987,0.006890896,0.006939245,0.00001226443,0.00007002753,0.001774884,0.000049997,0.001800675,0.9589886,0.000140367,0.02252525,0.00002542814],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884277,0.004159336,0.00137935,0.0002123933,0.0001290001,0.0000676793,0.0004474826,0.0001003775,0.005076737],"genre_scores_gemma":[0.9936419,0.001740246,0.001535756,0.0000678923,0.00006158504,0.00004072138,0.0004594408,0.000006540584,0.00244585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001394627,"threshold_uncertainty_score":0.004665494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005375378291756762,"score_gpt":0.2118830571245406,"score_spread":0.2065076788327839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}