{"id":"W2176270777","doi":"10.1016/j.bmcl.2004.07.025","title":"Synthesis and evaluation of 4-(1-aminoalkyl)-N-(4-pyridyl)cyclohexanecarboxamides as Rho kinase inhibitors and neurite outgrowth promoters","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Neurite; Promoter; Kinase; Chemical synthesis; Stereochemistry; Enzyme inhibitor; Biochemistry; Enzyme; In vitro; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000265064,0.0003275961,0.0003337385,0.0002458828,0.0002304151,0.0002352282,0.0003657707,0.0002363449,0.001672255],"category_scores_gemma":[0.0002494662,0.000177872,0.0002515503,0.0001999583,0.0001954355,0.0002198221,0.0001827645,0.000360709,0.0005288079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003577,"about_ca_system_score_gemma":0.0004272364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00105719,"about_ca_topic_score_gemma":0.002090918,"domain_scores_codex":[0.9998276,0.00004000997,0.00001738023,0.00002307448,0.00004644054,0.0000453487],"domain_scores_gemma":[0.9998817,0.00002106387,0.00003432075,0.00001478101,0.0000226403,0.00002545641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000368852,0.0001269667,0.00008448044,0.0001786398,0.000007661681,0.0002199698,0.00005023017,0.0005830535,0.9890499,0.0004097332,0.0001854504,0.008735178],"study_design_scores_gemma":[0.00008598382,0.0009819178,0.0007340253,0.0000129549,0.00001958842,0.0002266513,0.00001576602,0.0004973634,0.9913285,0.00003072826,0.00605338,0.00001313152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9691329,0.009554831,0.007747913,0.000221879,0.0001387786,0.0003427285,0.0005367913,0.0001922829,0.01213185],"genre_scores_gemma":[0.9785952,0.007178808,0.006329653,0.00006909602,0.00004913692,0.000192659,0.0005667983,0.00003504114,0.00698359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001672255,"threshold_uncertainty_score":0.005594313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008105382290701369,"score_gpt":0.227725767908705,"score_spread":0.2196203856180036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}