{"id":"W2176296348","doi":"10.1016/j.antiviral.2015.11.001","title":"Combination therapy including CpG oligodeoxynucleotides and entecavir induces early viral response and enhanced inhibition of viral replication in a woodchuck model of chronic hepadnaviral infection","year":2015,"lang":"en","type":"article","venue":"Antiviral Research","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Pfizer (Canada)","funders":"Deutsche Forschungsgemeinschaft; Wilhelm Sander-Stiftung","keywords":"Woodchuck hepatitis virus; Entecavir; CpG Oligodeoxynucleotide; Peripheral blood mononuclear cell; Immune system; Immunology; TLR9; Hepatitis B virus; CpG site; In vivo; Virology; Biology; Viral replication; Viral load; Virus; Medicine; Hepadnaviridae; In vitro; Lamivudine; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002407475,0.000581252,0.0005497875,0.000412349,0.0002630808,0.0002748674,0.0002620219,0.000408312,0.001387425],"category_scores_gemma":[0.0001361978,0.0002142349,0.0002534761,0.0001681285,0.0003571563,0.0003421293,0.0001512449,0.001119483,0.0002889484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002519265,"about_ca_system_score_gemma":0.0004789561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001250208,"about_ca_topic_score_gemma":0.003241599,"domain_scores_codex":[0.9997874,0.00005335932,0.000015805,0.0000396781,0.00003461782,0.00006917528],"domain_scores_gemma":[0.9998518,0.00002640051,0.0000241568,0.00001851121,0.00001406854,0.00006503484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002780212,0.0010248,0.000214785,0.00004468568,0.00001267504,0.00005248861,0.0000279041,0.0001474655,0.9926299,0.00007822606,0.00008658969,0.002900272],"study_design_scores_gemma":[0.0003995223,0.0217797,0.002643267,0.00001234274,0.00005765739,0.0001814488,0.00005638582,0.001173321,0.9724572,0.00005809453,0.001166508,0.00001474014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975038,0.0004742893,0.0007915418,0.00006252263,0.00007086702,0.00007702482,0.0001067482,0.00005024649,0.0008629201],"genre_scores_gemma":[0.9935699,0.0005301451,0.001680871,0.00004844415,0.00003538134,0.0001121616,0.0002395486,0.00001691353,0.003766597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001387425,"threshold_uncertainty_score":0.004641354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1589425796462765,"score_gpt":0.4176381085681958,"score_spread":0.2586955289219193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}