{"id":"W2176296348","doi":"10.1016/j.antiviral.2015.11.001","title":"Combination therapy including CpG oligodeoxynucleotides and entecavir induces early viral response and enhanced inhibition of viral replication in a woodchuck model of chronic hepadnaviral infection","year":2015,"lang":"en","type":"article","venue":"Antiviral Research","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Pfizer (Canada)","funders":"Deutsche Forschungsgemeinschaft; Wilhelm Sander-Stiftung","keywords":"Woodchuck hepatitis virus; Entecavir; CpG Oligodeoxynucleotide; Peripheral blood mononuclear cell; Immune system; Immunology; TLR9; Hepatitis B virus; CpG site; In vivo; Virology; Biology; Viral replication; Viral load; Virus; Medicine; Hepadnaviridae; In vitro; Lamivudine; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003345932,0.0001583441,0.0004044813,0.0007306739,0.0001068464,0.00002675117,0.00005800765,0.0001484275,0.000001050552],"category_scores_gemma":[0.001317502,0.0001511137,0.00004200225,0.0005417921,0.0005071637,0.0005720791,0.0001911025,0.0004074185,0.000002741895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002957758,"about_ca_system_score_gemma":0.0002614113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004127916,"about_ca_topic_score_gemma":0.0005683725,"domain_scores_codex":[0.9975237,0.0005666069,0.0004911874,0.0004171143,0.000671353,0.0003301008],"domain_scores_gemma":[0.9987015,0.0002365501,0.0001645791,0.0003017117,0.0005302684,0.0000654366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002499996,0.0002928493,0.08958088,0.0001033013,0.0000262984,0.000003380942,0.002923245,0.00000561508,0.8842559,0.000831145,0.0000192297,0.0194581],"study_design_scores_gemma":[0.002749667,0.002983985,0.3571798,0.0003424742,0.000009158054,0.000002429625,0.0001053287,0.004830346,0.6287107,0.002975377,0.000005637274,0.0001050206],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978231,0.0004324642,0.0001692779,0.0003524716,0.00002381447,0.0008103198,0.000009966215,0.00002681389,0.0003517987],"genre_scores_gemma":[0.9979597,0.001649523,0.0001359611,0.00001808618,0.00003381062,0.0001008248,0.00001178089,0.00002077929,0.00006948362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2675989,"threshold_uncertainty_score":0.6240203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1589425796462765,"score_gpt":0.4176381085681958,"score_spread":0.2586955289219193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}